EGFR-IN-87
EGFR-IN-87 (Compound Example 2) is a EGFR tyrosine kinase inhibitor. EGFR-IN-87 has IC50 value of 3.1 nM, 1.3 nM and 7.1 nM for EGFR_d746-750, EGFR_L858R/T790 and EGFR_WT in A431 cells, respectively. EGFR-IN-87 can be used for cancer diseases research.
For research use only. We do not sell to patients.
- CAS No.: 1835666-87-9
- Formula: C28H33N7O2
- Molecular Weight:499.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
Description
IC50 & Target
EGFR tyrosine kinase inhibitor for treatment of cancer, IC50 for EGFR d746~750, EGFR L858R/T790, EGFR WT was in nanomolar level.;WO2017120429(Example 2);陈婷婷要求上线,2023/9/15
Chemical Information
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CAS No. 1835666-87-9
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Molecular Weight 499.61
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Formula C28H33N7O2
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SMILES
O=C(NC1=CC(NC2=NC=CC(N3C=C(C)C4=C3C=CC=C4)=N2)=C(C=C1N(CCN(C)C)C)OC)C=C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)