EGFR-IN-87
EGFR-IN-87 (Compound Example 2) is a EGFR tyrosine kinase inhibitor. EGFR-IN-87 has IC50 value of 3.1 nM, 1.3 nM and 7.1 nM for EGFR_d746-750, EGFR_L858R/T790 and EGFR_WT in A431 cells, respectively. EGFR-IN-87 can be used for cancer diseases research.
For research use only. We do not sell to patients.
- CAS No.: 1835666-87-9
- Formula: C28H33N7O2
- Molecular Weight:499.61
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
More
Biological Activity
EGFR tyrosine kinase inhibitor for treatment of cancer, IC50 for EGFR d746~750, EGFR L858R/T790, EGFR WT was in nanomolar level.;WO2017120429(Example 2);陈婷婷要求上线,2023/9/15
Chemical Information
-
CAS No. 1835666-87-9
-
Molecular Weight 499.61
-
Formula C28H33N7O2
-
SMILES
O=C(NC1=CC(NC2=NC=CC(N3C=C(C)C4=C3C=CC=C4)=N2)=C(C=C1N(CCN(C)C)C)OC)C=C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)