2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR ligand-2

EGFR ligand-2 (compound C4), a covalent EGFR ligand, is a EGFR mutant inhibitor with IC50s of 21 nM and 48 nM for EGFRL858R and EGFRL858R/T790M, respectively. EGFR ligand-2 can be used to synthesize PROTAC.

For research use only. We do not sell to patients.

EGFR ligand-2 Chemical Structure

EGFR ligand-2 Chemical Structure

CAS No. : 2737283-20-2

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EGFR ligand-2 Related Antibodies

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Description

EGFR ligand-2 (compound C4), a covalent EGFR ligand, is a EGFR mutant inhibitor with IC50s of 21 nM and 48 nM for EGFRL858R and EGFRL858R/T790M, respectively. EGFR ligand-2 can be used to synthesize PROTAC[1].

IC50 & Target[1]

EGFRL858R

21 nM (IC50)

EGFRL858R/T790M

48 nM (IC50)

Molecular Weight

537.66

Formula

C30H35N9O
CAS No.
SMILES

C=CC(N1CCC[C@@H](C1)N2C(NC3=CC=CC=C3)=NC4=CN=C(N=C42)NC5=CC=C(C=C5)N6CCN(CC6)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR ligand-2 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR ligand-22737283-20-2EGFR ligand2EGFR ligand 2EGFREpidermal growth factor receptorErbB-1HER1EGFR ligandEGFR mutantPROTACInhibitorinhibitorinhibit

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