2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. ER121

ER121 (SGI-078) is an orally active non-toxic small molecule ErbB2 kinase inhibitor. ER121 shows potent antitumor activity can be used for the research of HER2-related breast cancer.

For research use only. We do not sell to patients.

ER121

ER121 Chemical Structure

CAS No. : 2360839-74-1

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Based on 1 publication(s) in Google Scholar

ER121 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

ER121 (SGI-078) is an orally active non-toxic small molecule ErbB2 kinase inhibitor. ER121 shows potent antitumor activity can be used for the research of HER2-related breast cancer[1].

IC50 & Target[1]

ErbB2

 

Molecular Weight

487.95

Formula

C24H27ClFN5O3
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(NC1=CC2=C(NC3=CC=C(C(Cl)=C3)F)N=CN=C2C=C1OCC)/C=C/CN(CCCO)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (25.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0494 mL 10.2470 mL 20.4939 mL
5 mM 0.4099 mL 2.0494 mL 4.0988 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0494 mL 10.2470 mL 20.4939 mL 51.2348 mL
5 mM 0.4099 mL 2.0494 mL 4.0988 mL 10.2470 mL
10 mM 0.2049 mL 1.0247 mL 2.0494 mL 5.1235 mL
15 mM 0.1366 mL 0.6831 mL 1.3663 mL 3.4157 mL
20 mM 0.1025 mL 0.5123 mL 1.0247 mL 2.5617 mL
25 mM 0.0820 mL 0.4099 mL 0.8198 mL 2.0494 mL
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ER121 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ER1212360839-74-1 SGI-078ER 121ER-121SGI078SGI 078EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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