Eritadenine
Based on 1 publication(s) in Google Scholar
Eritadenine (D-Eritadenine) is a potent AdoHcyase inhibitor, with an IC50 value of 7 nM. Eritadenine is also an acyclic sugar adenosine analogue. Eritadenine exhibits an inhibitory effect on the growth of Cryptosporidium parvum, with a MIC50 of 3 μM. Eritadenine can be used in the research of colorectal adenocarcinoma.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.76%
- CAS No.: 23918-98-1
- 화학식: C9H11N5O4
- 분자량:253.21
-
보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocol
- 순도&문서
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Eritadenine
MoreAll Parasite Isoforms
More
Biological Activity
제품 설명
IC50 & Target
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
0.03 μM
Compound: eritadenine
|
Inhibition of S-adenosyl-L-homocysteine hydrolase in intact rat hepatocytes
Inhibition of S-adenosyl-L-homocysteine hydrolase in intact rat hepatocytes
|
[PMID: 19692248] |
In Vitro
D-Eritadenine (IC50 = 7 nM) exerts a potent inhibitory effect on S-adenosylhomocysteine hydrolase (AdoHcyase)[1].
D-Eritadenine (MIC50 = 3 μM) exhibits a inhibitory effect on the growth of Cryptosporidium parvum[2].
D-Eritadenine (1 mM; 48 h) shows low cytotoxicity to uninfected HCT-8 cells, with a cell viability rate of 80%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 23918-98-1
-
Appearance Solid
-
분자량 253.21
-
화학식 C9H11N5O4
-
Color White to off-white
-
SMILES
O=C([C@@H]([C@@H](CN1C=NC2=C(N=CN=C12)N)O)O)O
-
Synonyms
Lentinacin; D-Eritadenine; Lentysine
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
J Oral Biosci
2025 Jun;67(2):100658. PMID: 40180282
Protocol
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
-
Data Sheet (276 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Huang Y, et al. Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. J Biol Chem. 2002 Mar 1;277(9):7477-82. [Content Brief]
[2]. Ctrnáctá V, et al. Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro. Exp Parasitol. 2010 Oct;126(2):113-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Eritadenine Related Classifications
HY-114866 Related Classifications
Powered by Bioz