Arrestin Modulator
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VUF11207 fumarate
0 ImagesVUF11207 fumarate is a potent, selective, and orally active CXCR7/ACKR3 agonist (pKi = 8.1). VUF11207 fumarate specifically activates CXCR7/ACKR3, recruits β-arrestin, and induces receptor internalization, while downregulating the pro-inflammatory, pro-osteoclastogenic, and tumor immunosuppressive signaling mediated by the CXCL12-CXCR4 axis. VUF11207 fumarate can be used for research on glioblastoma, hypertension, and venous thrombosis.
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VUF11207
0 ImagesCat. No.: HY-100677CAS No.: 1378524-41-4VUF11207 is a potent, selective, and orally active CXCR7/ACKR3 agonist (pKi = 8.1). VUF11207 specifically activates CXCR7/ACKR3, recruits β-arrestin, and induces receptor internalization, while downregulating the pro-inflammatory, pro-osteoclastogenic, and tumor immunosuppressive signaling mediated by the CXCL12-CXCR4 axis. VUF11207 can be used for research on glioblastoma, hypertension, and venous thrombosis.
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VUF11207 TFA
0 ImagesCat. No.: HY-115615CAS No.: 1492153-74-8VUF11207 TFA is a potent, selective, and orally active CXCR7/ACKR3 agonist (pKi = 8.1). VUF11207 TFA specifically activates CXCR7/ACKR3, recruits β-arrestin, and induces receptor internalization, while downregulating the pro-inflammatory, pro-osteoclastogenic, and tumor immunosuppressive signaling mediated by the CXCL12-CXCR4 axis. VUF11207 TFA can be used for research on glioblastoma, hypertension, and venous thrombosis.
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Arrestin-3 modulator-1
0 ImagesCat. No.: HY-175178CAS No.: 1214645-87-0Arrestin-3 modulator-1 (Compound LSH-3) is an arrestin-3 modulator. Arrestin-3 modulator-1 binds arrestin-3 at the interdomain interface. Arrestin-3 modulator-1 enhances recruitment of arrestin-3 to phosphorylation-deficient β2AR in cells with increase of FRET levels. Arrestin-3 modulator-1 can be used for congenital disorders like retinal degeneration, hyperthyroidism and obesity research.
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VUF11207 fumarate (Standard)
0 ImagesCat. No.: HY-110318RCAS No.: 1785665-61-3VUF11207 fumarate Standard is the analytical standard of VUF11207 fumarate (HY-110318). This product is intended for research and analytical applications. VUF11207 fumarate is a potent, selective, and orally active CXCR7/ACKR3 agonist (pKi = 8.1). VUF11207 fumarate specifically activates CXCR7/ACKR3, recruits β-arrestin, and induces receptor internalization, while downregulating the pro-inflammatory, pro-osteoclastogenic, and tumor immunosuppressive signaling mediated by the CXCL12-CXCR4 axis. VUF11207 fumarate can be used for research on glioblastoma, hypertension, and venous thrombosis.
