AS115
AS115 is a potent and selective KIAA1363 inactivator with IC50 value of 150 nM. KIAA1363 is a 2-acetyl monoacylglycerol ether (MAGE) hydrolase that is upregulated in aggressive cancers of various tissues.
For research use only. We do not sell to patients.
- CAS No.: 926657-43-4
- Formula: C21H32FNO4
- Molecular Weight:381.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
AS115 (10 μM, 4 h) can significantly reduce the formation of MAGE, alkyl lysophosphatidylcholine and alkyl lysophosphatidic acid in SKOV3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 926657-43-4
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Molecular Weight 381.48
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Formula C21H32FNO4
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SMILES
FC(C=CC=C1)=C1OC(NCCOC[C@H]2[C@H](CCCC2)COCCCC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chiang KP, et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol. 2006 Oct;13(10):1041-50. [Content Brief]
[2]. Jessani N, et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10335-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS115 Related Classifications
HY-114056 Related Classifications
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