DBIBB
Based on 2 publication(s) in Google Scholar
DBIBB is a specific nonlipid agonist of the type 2 G protein coupled receptor for lysophosphatidic acid (LPA2). DBIBB mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation, and reduces apoptosis. DBIBB represents a agent candidate capable of mitigating acute radiation syndrome caused by high-dose γ-radiation to the hematopoietic and gastrointestinal system.
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 1569309-92-7
- Formula: C23H20N2O6S
- Molecular Weight:452.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) DBIBB
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MEF | EC50 |
0.11 μM
Compound: 5
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Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay
Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay
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[PMID: 25100502] |
Chemical Information
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CAS No. 1569309-92-7
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Appearance Solid
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Molecular Weight 452.48
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Formula C23H20N2O6S
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Color Off-white to light brown
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SMILES
O=C(N1CCCCNS(C2=C(C=CC=C2)C(O)=O)(=O)=O)C3=C4C(C=CC=C4C1=O)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Exp Eye Res
Lysophosphatidic acid receptor 3 (LPAR3) regulates ocular surface chloride transport via calcium signaling. [Abstract]2025 Jun:255:110346. PMID: 40112945 -
Solvent & Solubility
DMSO : ≥ 100 mg/mL (221.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2100 mL | 11.0502 mL | 22.1004 mL | 55.2511 mL |
| 5 mM | 0.4420 mL | 2.2100 mL | 4.4201 mL | 11.0502 mL | |
| 10 mM | 0.2210 mL | 1.1050 mL | 2.2100 mL | 5.5251 mL | |
| 15 mM | 0.1473 mL | 0.7367 mL | 1.4734 mL | 3.6834 mL | |
| 20 mM | 0.1105 mL | 0.5525 mL | 1.1050 mL | 2.7626 mL | |
| 25 mM | 0.0884 mL | 0.4420 mL | 0.8840 mL | 2.2100 mL | |
| 30 mM | 0.0737 mL | 0.3683 mL | 0.7367 mL | 1.8417 mL | |
| 40 mM | 0.0553 mL | 0.2763 mL | 0.5525 mL | 1.3813 mL | |
| 50 mM | 0.0442 mL | 0.2210 mL | 0.4420 mL | 1.1050 mL | |
| 60 mM | 0.0368 mL | 0.1842 mL | 0.3683 mL | 0.9209 mL | |
| 80 mM | 0.0276 mL | 0.1381 mL | 0.2763 mL | 0.6906 mL | |
| 100 mM | 0.0221 mL | 0.1105 mL | 0.2210 mL | 0.5525 mL |
DBIBB Related Classifications
HY-117779 Related Classifications
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