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Cat. No.: HY-181987

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PSCdb01560

PSCdb01560 is a Dengue virus NS5 RNA-dependent RNA polymerase (RdRp) inhibitor. PSCdb01560 binds stably to the conserved allosteric N-pocket of the polymerase, maintains persistent interactions with key residues Arg729 and Arg737, and induces polymerase structure stabilization. PSCdb01560 can be used for the research of dengue virus infection.

For research use only. We do not sell to patients.

Formula: C₁₈H₂₀O₅
Molecular Weight:316.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PSCdb01560 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

RNA Polymerase

All DNA/RNA Synthesis Isoforms :

In Vitro

PSCdb01560 forms a thermodynamically stable, tightly bound complex with dengue virus NS5 RdRp (PDB: 5K5M), exhibiting superior dynamic stability, minimal conformational drift, and a more favourable post-MD MM-GBSA binding free energy (-91.65 ± 4.02 kcal/mol) than the reference inhibitor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 316.35
Formula C₁₈H₂₀O₅
SMILES

COC1=CC=C(C[C@H](O)C(C2=CC=C(OC)C=C2OC)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alsaady IM, et al. Conformational dynamics and binding free energy analyses unveil a stable flavonoid inhibitor of dengue virus NS5 polymerase. Sci Rep. 2026;16(1):7761. Published 2026 Feb 7. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PSCdb01560

All DNA/RNA Synthesis Isoforms