FDA-Approved Drug Library Mini
Based on 100 publication(s) in Google Scholar
New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.
MCE owns a unique collection of 3,236 approved compounds which have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. The package of this library is 96-well microplate with peelable foil seal, which makes the screening process easier and faster.
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Description & Advantages
• A unique collection of 3,236 approved drugs for high throughput screening (HTS) and high content screening (HCS).
• Used in the research of oncology, cardiology, anti-inflammatory, immunology, dermatology, endocrinology, neurology, and more.
• A useful tool for researching new targets of marketed old drugs.
• All compounds have been approved by the FDA, EMA and other countries.
• Structurally diverse, bioactive, and cell permeable.
• More detailed compound information with structure, IC50, and brief introduction.
• NMR and HPLC validated ensure high purity.
• All compounds are in stock and continuously updated.
| FDA-Approved Drug Library Mini | FDA-Approved Drug Library (Cat. No.: HY-L022) | |
|---|---|---|
| Size | 10 μL in DMSO | 30, 50, 100, and 200 μL in DMSO |
| Package | 96-well microplate with peelable foil seal | 96-Well Format Sample Storage Tube With Screw Cap |
| Delivery Date | Within three days | About one month |
| Price Per Set | Low | High |
| Preparation For Use | Tear off the seal film on the microplate | If there is no robot, each tube needs to be manually opened |
• Easily peelable foil seal makes the screening process easier and faster.
• Lower price, more compounds.
• Avoid multiple and uneven dispensing.
• Reduce risks of product cross-contamination.
• Avoid reduced activity due to long-term storage.
Product Details
A collection of 3,236 marketed drugs supplied as pre-dissolved Solutions
Solution: 3,142 compounds supplied in 10 mM solution, 65 compounds supplied in 2 mM solution, 29 compounds supplied in 3 mg/mL solution.
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
96-well Plate With Peelable Foil Seal
Publications (100)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Signal Transduct Target Ther
Z-DNA-binding protein 1 exacerbates myocardial ischemia‒reperfusion injury by inducing noncanonical cardiomyocyte PANoptosis. [Abstract]2025 Oct 7;10(1):333. PMID: 41052986 -
Chem Rev
2020 Oct 28;120(20):11616-11650. PMID: 32930577 -
Nat Med
2017 Apr 7;23(4):405-408. PMID: 28388612 -
Circulation
Novel CaMKII-δ Inhibitor Hesperadin Exerts Dual Functions to Ameliorate Cardiac Ischemia/Reperfusion Injury and Inhibit Tumor Growth. [Abstract]2022 Apr 12;145(15):1154-1168. PMID: 35317609 -
Nat Commun
Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4. [Abstract]2026 May 5;17(1):4062. PMID: 42086561 -
Nat Commun
2025 Nov 13;16(1):9860. PMID: 41233320 -
Nat Commun
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. [Abstract]2020 Sep 4;11(1):4417. PMID: 32887884 -
Nat Commun
Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors. [Abstract]2018 Apr 26;9(1):1677. PMID: 29700304 -
J Adv Res
LTX-315 is a novel broad-spectrum antimicrobial peptide against clinical multidrug-resistant bacteria. [Abstract]2025 Jan 9:S2090-1232(24)00621-0. PMID: 39793961 -
Metabolism
2026 Jul:180:156622. PMID: 41997496 -
Mol Cell
2025 Jul 3;85(13):2581-2596.e6. PMID: 40555234 -
Acta Pharm Sin B
Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]2021 Jan;11(1):143-155. PMID: 33532186 -
J Biomed Sci
STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening. [Abstract]2018 Aug 2;25(1):60. PMID: 30068339 -
Adv Sci (Weinh)
Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness. [Abstract]2026 Jun 16:e16501. PMID: 42299748 -
Adv Sci (Weinh)
Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin-mediated Phagocytic Effects for Lung Cancer Treatment. [Abstract]2025 Sep 23:e08245. PMID: 40985476 -
Adv Sci (Weinh)
Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin-induced Intestinal Injury by Production of Carboxylesterase EstB. [Abstract]2025 Dec 12:e17747. PMID: 41387308 -
Adv Sci (Weinh)
Targeting Caveolin-1 in Multiple Myeloma Cells Enhances Chemotherapy and Natural Killer Cell-Mediated Immunotherapy. [Abstract]2024 Dec 4:e2408373. PMID: 39630017 -
Sci Adv
Quantitative prediction of siRNA complexation by ionizable drugs enables their codelivery in nanoparticles. [Abstract]2026 Jun 12;12(24):eaed2731. PMID: 42284421 -
Cancer Lett
2026 Apr 1:642:218300. PMID: 41651400 -
J Exp Med
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition. [Abstract]2023 Mar 6;220(3):e20221316. PMID: 36520461 -
Cell Death Discov
2023 Dec 1;9(1):435. PMID: 38040674 -
Arthritis Rheumatol
Deficiency of cartilage-specific Y-box binding protein 1 represses NF-κB signaling and alleviates osteoarthritis progression. [Abstract]2025 Jul 14. PMID: 40654155 -
Proc Natl Acad Sci U S A
CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma. [Abstract]2025 Sep 30;122(39):e2519568122. PMID: 40991439 -
Cell Chem Biol
2026 Apr 27:S2451-9456(26)00110-8. PMID: 42049033 -
Cell Chem Biol
An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels. [Abstract]2025 Nov 20;32(11):1381-1396.e8. PMID: 41218609 -
Clin Transl Med
Functional genomics pipeline identifies CRL4 inhibition for the treatment of ovarian cancer. [Abstract]2025 Feb;15(2):e70078. PMID: 39856363 -
EMBO Mol Med
In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer. [Abstract]2022 Apr 7;14(4):e14608. PMID: 34927798 -
J Cheminform
HAMdb: a database of human autophagy modulators with specific pathway and disease information. [Abstract]2018 Jul 31;10(1):34. PMID: 30066211 -
Cell Rep
A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution. [Abstract]2017 Jul 25;20(4):999-1015. PMID: 28746882 -
Cell Syst
A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. [Abstract]2018 Apr 25;6(4):424-443.e7. PMID: 29655704 -
Anal Chem
Longitudinal Fragment Profiles Based on Multi-Collision Energy Tandem Mass Spectra Improve the Accuracy of Metabolite Identification in Untargeted Metabolomics. [Abstract]2025 Jul 15;97(27):14349-14360. PMID: 40592760 -
J Med Chem
From Experiments to a Fast Easy-to-Use Computational Methodology to Predict Human Aldehyde Oxidase Selectivity and Metabolic Reactions. [Abstract]2018 Jan 11;61(1):360-371. PMID: 29240409 -
Emerg Microbes Infect
A novel transcription and replication-competent virus-like particles system modelling the Nipah virus life cycle. [Abstract]2024 Jun 12:2368217. PMID: 38865205 -
J Invest Dermatol
Combined Cyclin-Dependent Kinase Inhibition Overcomes MAPK/Extracellular Signal-Regulated Kinase Kinase Inhibitor Resistance in Plexiform Neurofibroma of Neurofibromatosis Type I. [Abstract]2022 Mar;142(3 Pt A):613-623.e7. PMID: 34534577 -
Biochem Pharmacol
Direct reprogramming of human fibroblasts into hair-inducing dermal papilla cell-like cells by a single small molecule. [Abstract]2025 Jan 9:116744. PMID: 39798934 -
Biochem Pharmacol
Givinostat rescues folding of cystathionine beta-synthase and ameliorates murine homocystinuria. [Abstract]2025 Jun 24:239:117079. PMID: 40571220 -
Biochem Pharmacol
High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia. [Abstract]2023 Nov:217:115809. PMID: 37717691 -
Life Sci
Identification of novel CDK 9 inhibitors based on virtual screening, molecular dynamics simulation, and biological evaluation. [Abstract]2020 Oct 1;258:118228. PMID: 32781071 -
Front Pharmacol
CC-223, NSC781406, and BGT226 Exerts a Cytotoxic Effect Against Pancreatic Cancer Cells via mTOR Signaling. [Abstract]2020 Nov 11;11:580407. PMID: 33343350 -
Bioorg Chem
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation. [Abstract]2023 Dec:141:106880. PMID: 37783098 -
Molecules
A Novel Strategy for Regulating mRNA's Degradation via Interfering the AUF1's Binding to mRNA. [Abstract]2022 May 16;27(10):3182. PMID: 35630659 -
Int J Antimicrob Agents
Immunomodulator AS101 restores colistin susceptibility of clinical colistin-resistant Escherichia coli and Klebsiella pneumoniae in vitro and in vivo. [Abstract]2024 Aug 5:107285. PMID: 39111708 -
Sci Rep
Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. [Abstract]2017 Oct 16;7(1):12881. PMID: 29038464 -
ACS Infect Dis
Repurposing GSK2018682 Confers Dual Antibacterial and Antibiofilm Activity against Staphylococcus aureus. [Abstract]2026 Feb 13;12(2):623-636. PMID: 41525229 -
iScience
Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase. [Abstract]2024 Sep 16;27(10):110967. PMID: 39429773 -
iScience
2022 Jan 5;25(2):103731. PMID: 35098100 -
BMC Bioinformatics
Modeling drug mechanism of action with large scale gene-expression profiles using GPAR, an artificial intelligence platform. [Abstract]2021 Jan 7;22(1):17. PMID: 33413089 -
Epigenetics Chromatin
2020 Aug 3;13(1):31. PMID: 32746900 -
Nanomedicine
Improving lipid nanoparticles delivery efficiency of macrophage cells by using immunomodulatory small molecules. [Abstract]2025 Feb 3:64:102809. PMID: 39904398 -
Viruses
Identifying Inhibitors of -1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses. [Abstract]2022 Jan 18;14(2):177. PMID: 35215770 -
J Med Virol
Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca2+ -dependent membrane fusion. [Abstract]2021 Oct;93(10):5825-5832. PMID: 34061377 -
Toxicol Appl Pharmacol
Drug screening reveals the mechanism of toyocamycin-induced apoptosis in triple-negative breast cancer organoids. [Abstract]2026 Jan:506:117659. PMID: 41314261 -
ACS Chem Biol
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. [Abstract]2016 Dec 16;11(12):3400-3411. PMID: 27768280 -
ACS Chem Biol
2016 May 20;11(5):1245-54. PMID: 26863403 -
Bioorg Med Chem
Identification of a novel Aurora B inhibitor using the AI-driven drug screening and docking-based traditional screening. [Abstract]2025 Sep 27:131:118423. PMID: 41033076 -
SLAS Discov
An MRC-5 cell based high-throughput, high-content imaging assay to identify hits against Trypanosoma cruzi intracellular parasites. [Abstract]2026 Feb 17:39:100298. PMID: 41713554 -
SLAS Discov
Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates. [Abstract]2025 Apr:32:100224. PMID: 40024444 -
SLAS Discov
2020 Sep;25(8):895-905. PMID: 32567455 -
Biol Reprod
Strong inhibition of neutrophil-sperm interaction in cattle by selective phosphatidylinositol 3-kinase inhibitors. [Abstract]2017 Nov 1;97(5):671-687. PMID: 29036279 -
J Comput Aided Mol Des
Discovery of potent and selective LRRK2 inhibitors with preserved activity against the G2019S mutant via multi-stage virtual screening. [Abstract]2026 Jun 6;40(1):139. PMID: 42249205 -
J Comput Aided Mol Des
Synergistic approach utilizing bioinformatics, machine learning, and traditional screening for the identification of novel CSK inhibitors targeting hepatocellular carcinoma. [Abstract]2025 Nov 8;39(2):119. PMID: 41204015 -
ChemistryOpen
Discovery of Potential GPRC5D Inhibitors through Virtual Screening and Molecular Dynamics Simulations. [Abstract]2025 Sep 7:e202500360. PMID: 40914945 -
J Am Soc Mass Spectrom
2026 Jan 7;37(1):8-12. PMID: 41324382 -
PLoS One
Antibiofilm and antibacterial activity of maslinic acid against Vancomycin-Resistant Enterococci (VRE). [Abstract]2026 Feb 10;21(2):e0342234. PMID: 41666236 -
J Appl Microbiol
Antimicrobial compounds from an FDA-approved drug library with activity against Streptococcus suis. [Abstract]2022 Mar;132(3):1877-1886. PMID: 34800069 -
Clin Transl Oncol
Phenotypical screening on metastatic PRCC-TFE3 fusion translocation renal cell carcinoma organoids reveals potential therapeutic agents. [Abstract]2022 Jul;24(7):1333-1346. PMID: 35118587 -
Reprod Biol
Novel screening approach for stem cell selective inhibitors and their possible translational therapeutic potential for endometriosis. [Abstract]2025 Jan 11;25(1):100992. PMID: 39799809 -
Biochem Biophys Res Commun
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]2018 Sep 3;503(1):297-303. PMID: 29890135 -
Biochem Biophys Res Commun
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]2018 Sep 3;503(1):297-303. PMID: 29890135 -
In Vitro Cell Dev Biol Anim
The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene. [Abstract]2016 Apr;52(4):488-96. PMID: 26822431 -
Biol Open
2026 Feb 15;15(2):bio062380. PMID: 41601273 -
Assay Drug Dev Technol
Automated Assays to Identify Modulators of Transcription Factor EB Translocation and Autophagy. [Abstract]2022 Feb-Mar;20(2):67-74. PMID: 34898267 -
bioRxiv
EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA. [Abstract]2026 Jun 5:2026.06.02.729650. PMID: 42282735 -
bioRxiv
Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen. [Abstract]2023 May 10:2021.05.15.444128. PMID: 34159337 -
bioRxiv
Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen. [Abstract]2023 May 10:2021.05.15.444128. PMID: 34159337 -
bioRxiv
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19. [Abstract]2020 Dec 7:2020.05.27.117184. PMID: 32577649 -
Acta Med Iran
Precision Medicine Approach to Anaplastic Thyroid Cancer: Advances in Targeted Drug Therapy Based on Specific Signaling Pathways. [Abstract]2017 Mar;55(3):200-208. PMID: 28282720 -
J Biomol Screen
Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells. [Abstract]2015 Oct;20(9):1074-83. PMID: 26245650 -
Chem Biol
Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles. [Abstract]2015 Aug 20;22(8):1144-55. PMID: 26211361
Documentation
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Composition
Bacterial (585)
Apoptosis (477)
Antibiotic (445)
Autophagy (341)
Endogenous Metabolite (266)
Adrenergic Receptor (196)
Parasite (173)
5-HT Receptor (143)
Histamine Receptor (124)
COX (109)
Dopamine Receptor (109)
Calcium Channel (107)
Potassium Channel (102)
Fungal (100)
HIV (95)
mAChR (92)
NF-κB (86)
Sodium Channel (86)
DNA/RNA Synthesis (81)
SARS-CoV (74)
Cytochrome P450 (68)
Interleukin Related (63)
Influenza Virus (51)
Akt (50)
Ferroptosis (50)
Topoisomerase (46)
ERK (45)
GABA Receptor (44)
p38 MAPK (40)
NO Synthase (36)
HSV (35)
HCV (34)
nAChR (34)
VEGFR (34)
iGluR (32)
PPAR (32)
Cholinesterase (ChE) (31)
EGFR (31)
TRP Channel (31)
Beta-lactamase (30)
Drug Derivative (30)
Caspase (29)
Drug Metabolite (29)
Angiotensin Receptor (28)
PI3K (28)
TNF Receptor (28)
Mitophagy (27)
Microtubule/Tubulin (26)
PDGFR (26)
STAT (25)
JAK (24)
Monoamine Oxidase (24)
Amyloid-β (23)
c-Kit (22)
Carbonic Anhydrase (22)
JNK (22)
Orthopoxvirus (22)
FGFR (21)
HBV (21)
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Proton Pump (21)
mTOR (20)
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Androgen Receptor (18)
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MEK (18)
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CDK (16)
HIV Protease (16)
P-glycoprotein (16)
Bcl-2 Family (15)
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