UHMCP1
Based on 1 Customer Validation
UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a Kd of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties.
For research use only. We do not sell to patients.
- Purity : 99.68%
- CAS No.: 2103079-87-2
- Formula: C19H27N3
- Molecular Weight:297.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
Kd: 79 µM (UHM domain)[1]
In Vitro
UHMCP1 (25-400 μM) reduces the binding of purified U2AF65 to SF3b155 by 75%, exhibiting a simple, non-cooperative binding mode with Kd around 30 μM for U2AF65[1].
UHMCP1 (0-200 μM; 24 h) exhibits a certain effect on cell viability of HEK293[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 cells
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Concentration:0-100 µM
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Incubation Time:24 h
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Result:Inhibited cell viability with an EC50 value of 140 µM.
Chemical Information
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CAS No. 2103079-87-2
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Appearance Solid
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Molecular Weight 297.44
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Formula C19H27N3
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Color Light yellow to brown
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SMILES
CC(N(C[C@]1([H])CC2)C[C@]2([H])[C@H]1N)CCC3=CNC4=CC=CC=C34
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (336.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3620 mL | 16.8101 mL | 33.6202 mL | 84.0506 mL |
| 5 mM | 0.6724 mL | 3.3620 mL | 6.7240 mL | 16.8101 mL | |
| 10 mM | 0.3362 mL | 1.6810 mL | 3.3620 mL | 8.4051 mL | |
| 15 mM | 0.2241 mL | 1.1207 mL | 2.2413 mL | 5.6034 mL | |
| 20 mM | 0.1681 mL | 0.8405 mL | 1.6810 mL | 4.2025 mL | |
| 25 mM | 0.1345 mL | 0.6724 mL | 1.3448 mL | 3.3620 mL | |
| 30 mM | 0.1121 mL | 0.5603 mL | 1.1207 mL | 2.8017 mL | |
| 40 mM | 0.0841 mL | 0.4203 mL | 0.8405 mL | 2.1013 mL | |
| 50 mM | 0.0672 mL | 0.3362 mL | 0.6724 mL | 1.6810 mL | |
| 60 mM | 0.0560 mL | 0.2802 mL | 0.5603 mL | 1.4008 mL | |
| 80 mM | 0.0420 mL | 0.2101 mL | 0.4203 mL | 1.0506 mL | |
| 100 mM | 0.0336 mL | 0.1681 mL | 0.3362 mL | 0.8405 mL |
UHMCP1 Related Classifications
HY-148384 Related Classifications
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