Pipequaline
Based on 1 publication(s) in Google Scholar
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.93%
- No. CAS: 77472-98-1
- Fòrmula: C22H24N2
- Peso molecular:316.44
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Pipequaline
More
Actividad biológica
Descripciòn
IC50 & Target
Benzodiazepine receptor[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 77472-98-1
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Appearance Solid
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Peso molecular 316.44
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Fòrmula C22H24N2
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Color White to off-white
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SMILES
C1(C2=CC=CC=C2)=NC3=CC=CC=C3C(CCC4CCNCC4)=C1
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Synonyms
PK-8165
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Bioorg Chem
Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]2024 Jun:147:107412. PMID: 38696845
Solvente y solubilidad
In Vitro:
DMSO : ≥ 32 mg/mL (101.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
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Protocol for Elevated Plus Maze Test
The Elevated Plus Maze is a rodent anxiety-like behavior assay based on the conflict between spontaneous exploration and avoidance of open, elevated, exposed spaces. The apparatus contains two open arms and two closed arms arranged in a plus shape, and rodents normally spend more time in closed arms than open arms. The assay readout is generated by recording arm entries, time spent in open and closed arms, and related exploratory behaviors. Increased open-arm time or open-arm entries is commonly interpreted as reduced anxiety-like behavior, whereas reduced open-arm exploration is interpreted as increased anxiety-like behavior.
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Bradwejn J, et al. Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-inducedactivation of hippocampal pyramidal neurons: a microiontophoretic study in the rat. Eur J Pharmacol. 1985 Jun 19;112(3):415-8. [Content Brief]
[2]. Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1602 mL | 15.8008 mL | 31.6016 mL | 79.0039 mL |
| 5 mM | 0.6320 mL | 3.1602 mL | 6.3203 mL | 15.8008 mL | |
| 10 mM | 0.3160 mL | 1.5801 mL | 3.1602 mL | 7.9004 mL | |
| 15 mM | 0.2107 mL | 1.0534 mL | 2.1068 mL | 5.2669 mL | |
| 20 mM | 0.1580 mL | 0.7900 mL | 1.5801 mL | 3.9502 mL | |
| 25 mM | 0.1264 mL | 0.6320 mL | 1.2641 mL | 3.1602 mL | |
| 30 mM | 0.1053 mL | 0.5267 mL | 1.0534 mL | 2.6335 mL | |
| 40 mM | 0.0790 mL | 0.3950 mL | 0.7900 mL | 1.9751 mL | |
| 50 mM | 0.0632 mL | 0.3160 mL | 0.6320 mL | 1.5801 mL | |
| 60 mM | 0.0527 mL | 0.2633 mL | 0.5267 mL | 1.3167 mL | |
| 80 mM | 0.0395 mL | 0.1975 mL | 0.3950 mL | 0.9875 mL | |
| 100 mM | 0.0316 mL | 0.1580 mL | 0.3160 mL | 0.7900 mL |
Pipequaline Related Classifications
HY-100140 Related Classifications
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