Antimalarial agent 49
Antimalarial agent 49 is an orally active antimalarial compound. Antimalarial agent 49 inhibits growth of Pf3D7 and PfK1 strains (IC50: 0.84 μM and 0.4 μM respectively). Antimalarial agent 49 has antimalarial activity and inhibits the development of P. berghei liver stages. Antimalarial agent 49 can be used in the study of Plasmodium infection.
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- Fòrmula: C28H18F4N6O
- Peso molecular:530.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Antimalarial agent 49 (compound 15k) (0.37-10 μM, 40 h) inhibits the development of P. berghei liver stage (IC50: 5.88 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | Tmax | Plasma Concentration | Vd | Clearance (CL) | AUC | MRT |
|---|---|---|---|---|---|---|---|---|---|
| Mice[1] | 100 mg/kg | p.o. | 3.74 h | 4.00 h | 15.17 ng/mL | 4.97 L/kg | 0.92 L/h/kg | 0.11 ng·h/mL | 7.30 h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Swiss mice (6-8-week-old, 18 ± 2 g) were intra-peritoneally inoculated with 1x106 P.yoelii N67 infected red blood cells (iRBCs)[1]
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Dosage:100 mg/kg
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Administration:Oral gavage (p.o.), once every day for 4 d
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Result:Inhibited 42.55% of parasite growth on the 7th day and 35.93% of parasite growth on the 10th day.
Prolonged the median survival time (17 d) compared with the Chloroquine (HY-17589A) (10 mg/kg)-treated group (16 d).
Chemical Information
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Peso molecular 530.48
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Fòrmula C28H18F4N6O
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SMILES
O=C(C1=CC2=C(C(C3=CC=C(F)C=C3)=N1)NC4=C2C=CC=C4)NCC5=CN(C6=CC=CC(C(F)(F)F)=C6)N=N5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent 49 Related Classifications
HY-173312 Related Classifications
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