AT-9010
Based on 1 publication(s) in Google Scholar
AT-9010, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 can inhibit SARS-CoV-2 replication.
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- No. CAS: 1261253-79-5
- Fòrmula: C11H17FN5O13P3
- Peso molecular:539.20
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Publications Citing Use of MedChemExpress (MCE) AT-9010
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Actividad biológica
NiRAN[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>100 μM
Compound: 2-TP
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Inhibition of RNA polymerase 2 in human HeLa cell nuclear extract assessed as reduction in RNA transcription by polyacrylamide gel electrophoresis method
Inhibition of RNA polymerase 2 in human HeLa cell nuclear extract assessed as reduction in RNA transcription by polyacrylamide gel electrophoresis method
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[PMID: 32816483] |
| Huh-7 | CC50 |
>100 μM
Compound: 6
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Cytotoxicity against human HuH7 cells
Cytotoxicity against human HuH7 cells
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[PMID: 21050754] |
Substantial levels of the active triphosphate metabolite AT-9010 are formed in normal human bronchial and nasal epithelial cells incubated with 10 µM AT-511 (698 µM and 236 µM, respectively), with a half-life of at least 38 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1261253-79-5
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Peso molecular 539.20
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Fòrmula C11H17FN5O13P3
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SMILES
O[C@H]1[C@](F)(C)[C@H](N2C3=C(C(N=C(N3)N)=O)N=C2)O[C@@H]1COP(O)(OP(OP(O)(O)=O)(O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. [Abstract]2022 Nov 10;185(23):4347-4360.e17. PMID: 36335936
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AT-9010 Related Classifications
HY-139165 Related Classifications
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