Bupropion morpholinol
Based on 1 Customer Validation
Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities.
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- Pureza: 99.9%
- No. CAS: 357399-43-0
- Fòrmula: C13H18ClNO2
- Peso molecular:255.74
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Dopamine transporter[2], Norepinephrine transporter[2], α4β2 nicotinic receptor[2]
Bupropion morpholinol is produced from Bupropion by the genetically polymorphic enzyme CYP2B6 in vivo[1].
Bupropion morpholinol inhibits [3H]norepinephrine uptake with an IC50 of 1.7 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 357399-43-0
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Appearance Solid
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Peso molecular 255.74
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Fòrmula C13H18ClNO2
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Color White to off-white
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SMILES
OC1(C2=CC=CC(Cl)=C2)C(C)NC(C)(C)CO1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 20 mg/mL (78.20 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 20 mg/mL (78.20 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zhu AZX, et, al. CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. Clin Pharmacol Ther. 2012 Dec;92(6):771-7. [Content Brief]
[2]. Damaj MI, et, al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66(3):675-82. [Content Brief]
[3]. Damaj MI, et, al. Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice. J Pharmacol Exp Ther. 2010 Sep 1;334(3):1087-95. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 3.9102 mL | 19.5511 mL | 39.1022 mL | 97.7555 mL |
| 5 mM | 0.7820 mL | 3.9102 mL | 7.8204 mL | 19.5511 mL | |
| 10 mM | 0.3910 mL | 1.9551 mL | 3.9102 mL | 9.7756 mL | |
| 15 mM | 0.2607 mL | 1.3034 mL | 2.6068 mL | 6.5170 mL | |
| 20 mM | 0.1955 mL | 0.9776 mL | 1.9551 mL | 4.8878 mL | |
| 25 mM | 0.1564 mL | 0.7820 mL | 1.5641 mL | 3.9102 mL | |
| 30 mM | 0.1303 mL | 0.6517 mL | 1.3034 mL | 3.2585 mL | |
| 40 mM | 0.0978 mL | 0.4888 mL | 0.9776 mL | 2.4439 mL | |
| 50 mM | 0.0782 mL | 0.3910 mL | 0.7820 mL | 1.9551 mL | |
| 60 mM | 0.0652 mL | 0.3259 mL | 0.6517 mL | 1.6293 mL |
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