CAY10581
CAY10581, a pyranonaphthoquinone derivative, is a highly specific and reversible uncompetitive IDO Inhibitor with an IC50 of 55 nM.
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- No. CAS: 1018340-07-2
- Fòrmula: C22H21NO4
- Peso molecular:363.41
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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IDO 55 nM (IC50) |
CAY10581 (100 nM; 24 h) abrogates the growth inhibition by IFN-gamma in MSCs[1].
CAY10581 (compound 36) demonstrates minimal impact on T-REx cells viability at 100 μM after 24 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mesenchymal stem cells (MSCs)
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Concentration:100 nM
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Incubation Time:24 h post-treatment
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Result:Abrogated the growth inhibition by IFN-gamma (50 ng/ml) in MSCs.
Chemical Information
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No. CAS 1018340-07-2
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Peso molecular 363.41
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Fòrmula C22H21NO4
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SMILES
O=C1C2=C(C(C3=C1C=CC=C3)=O)[C@@H]([C@@H](C(C)(O2)C)O)NCC4=CC=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Sanjeev Kumar, et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. [Content Brief]
[2]. Siddaraju V Boregowda, et al. A Clinical Indications Prediction Scale Based on TWIST1 for Human Mesenchymal Stem Cells. EBioMedicine. 2015 Dec 24;4:62-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAY10581 Related Classifications
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