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Referencia número: HY-119236

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CP-432

(Synonyms: CP-734432)

CP-432 (CP-734432) is a EP4 receptor agonist with an IC₅₀ of 2 nM for human sources, 8 nM for canine sources, and an EC₅₀ of 1 nM for human sources. CP-432 stimulates cAMP production and activates β-lactamase (β-lactamase) activity via the cAMP response element signaling pathway. CP-432 is applicable to research related to glaucoma.

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No. CAS: 431990-08-8
Fòrmula: C₂₃H₂₆F₃NO₄S
Peso molecular:469.52

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

CP-432 Chemical Structure

No. CAS: 431990-08-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
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- IC₅₀ & Target
- Cellular Effect
- In Vitro
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

human EP4-R

2 nM (IC₅₀)

dog EP4

8 nM (IC₅₀)

human EP4-R

1 nM (EC₅₀)

Ver todos los productos específicos de isoformas Prostaglandin Receptor :

Ver todos los productos específicos de isoformas Beta-lactamase :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.5 nM Compound: 16c	Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation	[PMID: 16442794]
HEK293	EC₅₀	0.5 nM Compound: 50, CP432	Agonist activity at rat EP4 receptor expressed in HEK293 cells assessed as cAMP activation Agonist activity at rat EP4 receptor expressed in HEK293 cells assessed as cAMP activation	[PMID: 20218623]
HEK293	IC₅₀	483 nM Compound: 16c	Binding affinity to rat EP2 receptor expressed in HEK293 cells Binding affinity to rat EP2 receptor expressed in HEK293 cells	[PMID: 16442794]
HEK293	IC₅₀	6 nM Compound: 16c	Binding affinity to rat EP4 receptor expressed in HEK293 cells Binding affinity to rat EP4 receptor expressed in HEK293 cells	[PMID: 16442794]

In Vitro

CP-734432 (20 min) potently stimulates cAMP production in human EP4-expressing HEK293 cells with an EC₅₀ of 1 nM^[1].
CP-734432 (3 h pre-incubation; 3 h compound incubation; 2 h substrate incubation) potently activates human EP4 receptor-mediated CRE-β-lactamase signaling in CHO cells with an EC₅₀ of 1 nM, and shows high selectivity over human EP2 receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 431990-08-8
Peso molecular 469.52
Fòrmula C₂₃H₂₆F₃NO₄S
SMILES

C(C[C@H](CC1=CC(C(F)(F)F)=CC=C1)O)[C@@H]2N(CCCC=3SC(C(O)=O)=CC3)C(=O)CC2
Synonyms

CP-734432
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Prasanna G, et al. Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models. Exp Eye Res. 2009;89(5):608-617. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- In Vitro
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CP-432

Ver todos los productos específicos de isoformas Prostaglandin Receptor

Ver todos los productos específicos de isoformas Beta-lactamase

Actividad biológica

Chemical Information

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Referencias

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CP-432 Related Classifications

HY-119236 Related Classifications