country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-131206

Copy Link Print Information

DS37571084

DS37571084 is an orally active competitive antagonist of parathyroid hormone receptor 1 (PTH1R) with an IC₅₀ value of 0.17 μM. DS37571084 is applicable to the research of bone diseases and calcium metabolism disorders associated with primary hyperparathyroidism.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2460353-87-9
Fòrmula: C₂₈H₃₀Cl₂N₄O₂
Peso molecular:525.47

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

DS37571084 Chemical Structure

No. CAS: 2460353-87-9

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[2]

PTH1R

0.17 μM (IC₅₀)

Ver todos los productos específicos de isoformas PTHR :

PTH1R
PTH2R

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC50	0.17 μM	Inhibition of PTH-induced cAMP production in cAMP Hunter™ CHO-K1 PTHR1 Gs/Gq cells incubated for 30 min using a cAMP dynamic 2 kit. Inhibition of PTH-induced cAMP production in cAMP Hunter™ CHO-K1 PTHR1 Gs/Gq cells incubated for 30 min using a cAMP dynamic 2 kit.	39519190

In Vitro

DS37571084 (10-100 μM; 30 min) potently inhibits PTHR1-induced cAMP production in cAMP Hunter™ CHO-K1 PTHR1 Gs/Gq cells with an IC₅₀ of 0.17 μM^[1].
DS37571084 exhibits metabolic stability in rat liver microsomes, with 65% of the compound remaining after 20 min of incubation at 1 μM^[1].
DS37571084 shows no significant inhibitory activity against CYP 1A2, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, or CYP 3A4 at a concentration of 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Bioavailability	AUC_last	T_1/2	CL	V_d
Rat^[1]	10 mg/kg	p.o.	61 %	2.50 μg·h/mL	13.1 h	/	/
Rat^[1]	5 mg/kg	i.v.	/	/	/	39.0 mL/min/kg	29.4 L/kg

Chemical Information

No. CAS 2460353-87-9
Peso molecular 525.47
Fòrmula C₂₈H₃₀Cl₂N₄O₂
SMILES

O=C1N(C2=CC=C(NCCNC3CCOCC3)C=C2)C4=CC(Cl)=CC=C4C5=CC(Cl)=CN=C5C1(C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Arai Y, et al. Discovery of novel, potent, and orally bioavailable pyrido[2,3-d][1]benzazepin-6-one antagonists for parathyroid hormone receptor 1. Bioorganic & medicinal chemistry. 2020 Jun 01;28(11):115524. [Content Brief]

[2]. Iwanowska M, et al. Bone Disease in Primary Hyperparathyroidism-Changes Occurring in Bone Metabolism and New Potential Treatment Strategies. International journal of molecular sciences. 2024 Oct 30;25(21):11639.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

DS37571084

Ver todos los productos específicos de isoformas PTHR