CAMK2G - calcium/calmodulin dependent protein kinase II gamma Gene

Also Known as CAMK; CAMKG; MRD59; CAMK-II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 818

About CAMK2G

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,812,501-73,874,555 (from NCBI)

This gene has 27 transcripts (splice variants), 297 orthologues, 22 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 28.7), prostate (RPKM 10.9) and 24 other tissues.

Summary

The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the CA(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]

CAMK2G Products (79)

mRNA Protein Name
XR_007061995.1
XM_047425798.1 XP_047281754.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3
NM_001367542.1 NP_001354471.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 35
XM_005270198.2 XP_005270255.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4
NM_001367548.1 NP_001354477.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 41
NM_001367529.1 NP_001354458.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 22
NM_001367520.1 NP_001354449.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 13
XR_007061992.1
XM_047425805.1 XP_047281761.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X15
NM_001367547.1 NP_001354476.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 40
NM_001367524.1 NP_001354453.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 17
NM_001367516.1 NP_001354445.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 10
XR_001747218.2
NM_001367526.1 NP_001354455.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 19
XR_007061994.1
NM_001367540.1 NP_001354469.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 33
XR_007061999.1
NM_172172.1
NM_001367518.1 NP_001354447.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 11
XM_005270205.2 XP_005270262.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10
XR_007062000.1
NM_172171.3 NP_751911.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1
XM_006717998.2 XP_006718061.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6
NR_160263.1
NM_001367539.1 NP_001354468.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 32
NM_001367538.1 NP_001354467.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 31
NM_001367535.1 NP_001354464.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 28
NM_001367522.1 NP_001354451.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 15
XR_007061998.1
NR_160046.1
XM_047425801.1 XP_047281757.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8
NM_001367534.1 NP_001354463.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 27
NR_160045.1
NM_001204492.2 NP_001191421.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7
NM_001367528.1 NP_001354457.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 21
NM_001367536.1 NP_001354465.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 29
NM_001320898.2 NP_001307827.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 8
NR_160044.1
NM_001367523.1 NP_001354452.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 16
XM_047425800.1 XP_047281756.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7
NM_001367533.1 NP_001354462.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 26
NM_172170.5 NP_751910.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3
XR_007061993.1
NM_001367532.1 NP_001354461.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 25
NM_001367543.1 NP_001354472.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 36
NM_001367531.1 NP_001354460.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 24
XR_007061996.1
NR_160040.1
NM_001367546.1 NP_001354475.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 39
XR_007061991.1
XM_006717996.2 XP_006718059.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2
XM_024448218.2 XP_024303986.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X9
XM_047425799.1 XP_047281755.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5
NM_001367527.1 NP_001354456.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 20
NM_001367517.1 NP_001354446.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3
NM_172173.3 NP_751913.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 6
NM_001367530.1 NP_001354459.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 23
NM_001367521.1 NP_001354450.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 14
XM_047425802.1 XP_047281758.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X12
XM_047425804.1 XP_047281760.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X14
XR_007061990.1
XM_047425803.1 XP_047281759.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13
XR_945821.2
XR_007061997.1
XM_017016730.2 XP_016872219.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11
NM_001367519.1 NP_001354448.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 12
NR_160041.1
NM_001367537.1 NP_001354466.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 30
NM_001367544.1 NP_001354473.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 37
NR_160047.1
NM_001367514.1 NP_001354443.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 9
XM_047425797.1 XP_047281753.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1
NM_001222.4 NP_001213.2 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 4
XR_945822.2
NM_172169.3 NP_751909.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2
NM_001367545.1 NP_001354474.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 38
NR_160042.1
NM_001367541.1 NP_001354470.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 34
NM_001367525.1 NP_001354454.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 18

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
20668654 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20668654 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
20668654 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
30184290 GOA
Cellular Component GO Annotation Evidence Referencias Source
part of calcium- and calmodulin-dependent protein kinase complex IDA
IDA: Inferred from direct assay
20668654 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK2G Protein Structure

Pkinase

Pkinase: Protein kinase domain (14 - 272)

CaMKII_AD

CaMKII_AD: Calcium/calmodulin dependent protein kinase II association domain (424 - 551)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 556 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type II subunit gamma

  • caMK-II subunit gamma

  • calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma

CAMK2G Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
CAMK2G Q13555 CAMK2D Homo sapiens Q13557
Anti Tag CoIP
35271311
Intra
CAMK2G Q13555 CAMK2B Homo sapiens Q13554
Anti Tag CoIP
33961781
Intra
CAMK2G Q13555 CAMK2D Homo sapiens Q13557
Pull Down
32707033
Intra
CAMK2G Q13555 CAMK2G Homo sapiens Q13555
X-Ray Diffraction
20668654
Intra
CAMK2G Q13555 CAMK2A Homo sapiens Q9UQM7
Anti Tag CoIP
33961781
Intra
CAMK2G Q13555 CAMK2B Homo sapiens Q13554
Pull Down
32707033
Intra
CAMK2G Q13555 ARHGAP29 Homo sapiens Q52LW3
Pull Down
32707033
Intra
CAMK2G Q13555 CAMK2D Homo sapiens Q13557
Solution Sedimentation
20668654
Intra
CAMK2G Q13555 CAMK2A Homo sapiens Q9UQM7
Pull Down
32707033
Intra
CAMK2G Q13555 FKBP5 Homo sapiens Q13451
Pull Down
32707033
Intra
CAMK2G Q13555 CAMK2G Homo sapiens Q13555
Solution Sedimentation
20668654
Intra
CAMK2G Q13555 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
CAMK2G Q13555 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
22939624
Cross: Cross-species interaction Intra: Intraspecies interaction

CAMK2G Antibodies

Referencia número Nombre del producto Aplicación Reactivity
HY-P84551 CAMK2 gamma Antibody (YA4248) WB, IHC-P, FC, ELISA Human, Mouse, Rat, Monkey, Rabbit
HY-P84551A CAMK2 gamma Antibody (YA4248)(PBS only) WB, IHC-P, FC, ELISA Human, Mouse, Rat, Monkey, Rabbit
HY-P84930 CaMKII Antibody (YA4627) WB, IHC-P, IHC-F, ICC/IF, FC, IF-Tissue Human, Mouse, Rat, Monkey, Pig
HY-P86066 Phospho-CaMKIIβ/γ/δ Antibody (YA5758) IHC-P, ICC/IF Human, Rat, Mouse

Related Diseases

Diseases Alias
Nephronophthisis 11

  • NPHP11

  • Nephronophthisis, Type 11
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Breast Cancer

  • Breast Carcinoma

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Male Breast Cancer

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Intellectual Developmental Disorder, Autosomal Dominant 59

  • MRD59

  • Mental Retardation, Autosomal Dominant 59
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1

  • Cadasil

  • Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy

  • Casil

  • Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy

  • Familial Vascular Leukoencephalopathy

  • CADASIL1

  • Cadasil 1

  • Hereditary Multi-Infarct Dementia

  • Cadasil Syndrome

  • Dementia, Hereditary Multiinfarct Type

  • Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1

  • Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1

  • Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy

  • Dementia, Hereditary Multi-Infarct Type

  • Hereditary Dementia, Multi-Infarct Type

  • Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy

  • Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1

  • Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant

  • Dementia Hereditary Multiinfarct Type

  • Dementia Hereditary Multi-Infarct Type

  • Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS01859 CAMK2G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01860 Camk2g Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01861 CAMK2G Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CAMK2G VGNC VGNC:70525
Bos taurus CAMK2G VGNC VGNC:55982
Rattus norvegicus CAMK2G RGD RGD:621802
Felis catus CAMK2G VGNC VGNC:60334
Canis familiaris CAMK2G VGNC VGNC:38681
Mus musculus CAMK2G MGD MGI:88259
Others CAMK2G NCBI