KB-208
Based on 1 Customer Validation
KB-208 is a phagocytosis inhibitor. KB-208 inhibits phagocytosis of antibody-opsonized blood cells. KB-208 ameliorates thrombocytopenia in a mouse model of passive antibody-induced immune thrombocytopenia. KB-208 can be used for the research of immune thrombocytopenia.
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- Pureza: 98.00%
- No. CAS: 1282128-68-0
- Fòrmula: C22H23N3O3S
- Peso molecular:409.50
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
KB-208 inhibits phagocytosis of anti-D-opsonized Rh+ (R2R2) RBCs by human monocyte-macrophages[1].
KB-208 inhibits phagocytosis of anti-rabbit opsonized rabbit RBCs by mouse monocyte-macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
KB-208 (0.5-5 mg/kg; s.c., i.p.; twice daily on days 2 and 3) significantly increases platelet counts in female C57BL/6J mice with antibody-induced ITP[1].
KB-208 (2.5 mg/kg; i.p.; twice daily on days 2 and 3) significantly increases platelet counts in male and female outbred CD1 mice with antibody-induced ITP without altering other key blood parameters[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/cJ (female; antibody-induced ITP)[1]
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Dosage:0.5 mg/kg; 1 mg/kg; 2.5 mg/kg
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Administration:s.c.; twice daily on days 2 and 3; i.p.; twice daily on days 2 and 3
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Result:Elevated platelet counts relative to untreated controls after 2 days of 2.5 mg/kg subcutaneous injection.
Elevated platelet counts relative to untreated controls on day 1 of 2.5 mg/kg intraperitoneal injection.
Elevated platelet counts relative to untreated controls after 2 days of 1 mg/kg intraperitoneal injection.
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Animal Model:C57BL/6J (female; antibody-induced ITP)[1]
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Dosage:0.5 mg/kg; 1 mg/kg; 2.5 mg/kg; 5 mg/kg
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Administration:s.c.; twice daily on days 2 and 3; i.p.; twice daily on days 2 and 3
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Result:Elevated platelet counts relative to untreated controls on day 1 after 5 mg/kg subcutaneous administration.
Elevated platelet counts relative to untreated controls on day 2 after 2.5 mg/kg intraperitoneal administration.
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Animal Model:CD1 (male and female; antibody-induced ITP)[1]
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Dosage:2.5 mg/kg
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Administration:i.p.; twice daily on days 2 and 3
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Result:Elevated platelet counts on day 2 relative to untreated controls after 2.5 mg/kg intraperitoneal administration.
Exerted no influences on other blood parameters (WBC, RBC, HGB, HCT) during the 4-day testing period.
Chemical Information
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No. CAS 1282128-68-0
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Appearance Solid
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Peso molecular 409.50
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Fòrmula C22H23N3O3S
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Color White to off-white
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SMILES
O=C(CC1CCN(CC1)C(C2=CC(C3=CC=CS3)=NN2C4=CC=CC=C4)=O)OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (244.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (12.21 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4420 mL | 12.2100 mL | 24.4200 mL | 61.0501 mL |
| 5 mM | 0.4884 mL | 2.4420 mL | 4.8840 mL | 12.2100 mL | |
| 10 mM | 0.2442 mL | 1.2210 mL | 2.4420 mL | 6.1050 mL | |
| 15 mM | 0.1628 mL | 0.8140 mL | 1.6280 mL | 4.0700 mL | |
| 20 mM | 0.1221 mL | 0.6105 mL | 1.2210 mL | 3.0525 mL | |
| 25 mM | 0.0977 mL | 0.4884 mL | 0.9768 mL | 2.4420 mL | |
| 30 mM | 0.0814 mL | 0.4070 mL | 0.8140 mL | 2.0350 mL | |
| 40 mM | 0.0611 mL | 0.3053 mL | 0.6105 mL | 1.5263 mL | |
| 50 mM | 0.0488 mL | 0.2442 mL | 0.4884 mL | 1.2210 mL | |
| 60 mM | 0.0407 mL | 0.2035 mL | 0.4070 mL | 1.0175 mL | |
| 80 mM | 0.0305 mL | 0.1526 mL | 0.3053 mL | 0.7631 mL | |
| 100 mM | 0.0244 mL | 0.1221 mL | 0.2442 mL | 0.6105 mL |
KB-208 Related Classifications
HY-170506 Related Classifications
Powered by Bioz
- KB-208
- 1282128-68-0
- KB208
- KB 208
- Thrombopoietin Receptor
- passive antibody-induced immune thrombocytopenia mouse models
- immune thrombocytopenia
- antibody-opsonized blood cells
- C57BL/6J mice
- mouse monocyte-macrophages
- thrombocytopenia
- CD1 mice
- phagocytosis
- human monocyte-macrophages
- BALB/cJ mice
- Inhibitor
- inhibitor
- inhibit