Norbiotinamine
Based on 1 Customer Validation
Norbiotinamine is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction.
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- Pureza: 99.73%
- No. CAS: 173401-47-3
- Fòrmula: C9H17N3OS
- Peso molecular:215.32
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
In order to couple biotin to amino acids, reaction has to be with an amino group. An example is biocytin (biotin lysine). However, Norbiotinamine could be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction. As an example, Norbiotinamine is coupled with the NHS ester of N-Boc-glutamic acid γ-benzyl ester. The resulting norbiotinylamide of γglutamic acid (VII), obtained after deprotection, is similar to biocytin, but it has a shorter aliphatic chain and an inverted amide bond[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 173401-47-3
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Appearance Solid
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Peso molecular 215.32
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Fòrmula C9H17N3OS
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Color White to off-white
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SMILES
O=C1N[C@](CS[C@H]2CCCCN)([H])[C@]2([H])N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
H2O : 200 mg/mL (928.84 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (464.42 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Szalecki W.Synthesis of Norbiotinamine and its derivatives. Bioconjug Chem. 1996 Mar-Apr;7(2):271-3. [Content Brief]
[2]. Zhou GC, et al. Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells.Eur J Med Chem. 2013;70:631-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.6442 mL | 23.2210 mL | 46.4421 mL | 116.1052 mL |
| 5 mM | 0.9288 mL | 4.6442 mL | 9.2884 mL | 23.2210 mL | |
| 10 mM | 0.4644 mL | 2.3221 mL | 4.6442 mL | 11.6105 mL | |
| 15 mM | 0.3096 mL | 1.5481 mL | 3.0961 mL | 7.7403 mL | |
| 20 mM | 0.2322 mL | 1.1611 mL | 2.3221 mL | 5.8053 mL | |
| 25 mM | 0.1858 mL | 0.9288 mL | 1.8577 mL | 4.6442 mL | |
| 30 mM | 0.1548 mL | 0.7740 mL | 1.5481 mL | 3.8702 mL | |
| 40 mM | 0.1161 mL | 0.5805 mL | 1.1611 mL | 2.9026 mL | |
| 50 mM | 0.0929 mL | 0.4644 mL | 0.9288 mL | 2.3221 mL | |
| 60 mM | 0.0774 mL | 0.3870 mL | 0.7740 mL | 1.9351 mL | |
| 80 mM | 0.0581 mL | 0.2903 mL | 0.5805 mL | 1.4513 mL | |
| 100 mM | 0.0464 mL | 0.2322 mL | 0.4644 mL | 1.1611 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Norbiotinamine Related Classifications
HY-135717 Related Classifications
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