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Referencia número: HY-111147

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RDEA-427

RDEA-427 is a pyrrolopyrimidine derivative and also a HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). RDEA-427 acts on wild-type and NNRTI-resistant mutant HIV-1. RDEA-427 can be used in research related to HIV infection.

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No. CAS: 914496-19-8
Fòrmula: C₂₂H₁₆N₆O
Peso molecular:380.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

RDEA-427 Chemical Structure

No. CAS: 914496-19-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
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- In Vitro
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

HIV-1

Ver todos los productos específicos de isoformas HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	EC₅₀	0.9 nM Compound: RDEA427	Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25707013]

In Vitro

RDEA-427 (for 5 days) potently inhibits the replication of wild-type HIV-1 in MT4 cells, with an EC₅₀ of 0.9 nM and SI >50,000^[1].
RDEA-427 (for 5 days) inhibits the replication of NNRTI-resistant HIV-1^K103N-Y181C mutant strain in MT4 cells, and the EC₅₀ value against this mutant was 11‑fold higher than that against the wild‑type strain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 914496-19-8
Peso molecular 380.41
Fòrmula C₂₂H₁₆N₆O
SMILES

N#CC1=CC=C(C=C1)NC=2N=C(OC=3C(=CC(C#N)=CC3C)C)C=4C=CNC4N2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Tian Y, et al. Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives. Bioorg Med Chem. 2014 Apr 1;22(7):2052-9. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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- In Vitro
Chemical Information
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RDEA-427

Ver todos los productos específicos de isoformas HIV