Satranidazole
Satranidazole is an orally active insecticide and antimicrobial agent with high electron affinity. Satranidazole forms reduced nitro intermediates, which interact with DNA, causing helix instability, strand breakage and release of thymidine derivatives. Satranidazole exhibits antitrichomonal activity against Trichomonas vaginalis and Trichomonas foetus, and antiamoebic activity in rodent models of hepatic amoebiasis and caecal amoebiasis. Satranidazole inhibits the replication of bacteriophage φX174 DNA. Satranidazole can be used in research related to caecal amoebiasis, trichomoniasis and anaerobic bacterial infections.
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- No. CAS: 56302-13-7
- Fòrmula: C8H11N5O5S
- Peso molecular:289.27
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
Satranidazole induces extensive DNA damage in *E. coli* at compound-to-nucleotide ratios of 0.5:1 and 1:1, including helix destabilization, strand breakage, thymidine release, and reduced viscosity[1].
Satranidazole inactivates bacteriophage φX174 DNA at a compound-to-nucleotide ratio of 1:1, with a T37 of 2.41 h and an R37 of 3.85, indicating the presence of biologically relevant DNA damage[1].
Satranidazole (8 h) potently inhibits reference strains and clinical isolates of anaerobic bacteria in vitro, with an MIC90 of 0.25 mg/L against 50 clinical isolates, and its MIC values are lower than those of the control drugs in most tested strains[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Satranidazole demonstrates amoebicidal activity in a golden hamster model of liver, caecal, or combined Entamoeba histolytica infection[1].
Satranidazole exhibits superior activity to Metronidazole in a mouse model of subcutaneous Trichomonas vaginalis or Trichomonas foetus infection[1].
Satranidazole (2-32 mg/kg; p.o.; 3 doses) exhibits potent protective activity against fatal Fusobacterium necrophorum septicaemia in mice, with an ED50 of 2.10 mg/kg[2].
Satranidazole (10-100 mg/kg; p.o.; twice) demonstrates dose-dependent bactericidal activity against subcutaneous Bacteroides fragilis abscesses in mice, achieving a 3-log cfu reduction at 10 mg/kg and complete sterilization at 100 mg/kg[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MF2 strain (male, 18-20 g)[2]
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Dosage:2, 4, 8, 16, 32 mg/kg
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Administration:p.o.; at 24, 48, 72, and 96 hours post-infection
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Result:Exhibited an ED50 of 2.10 mg/kg, which was at least three-fold lower than the ED50 values of comparator drugs.
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Animal Model:MF2 strain (male, 18-20 g)[2]
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Dosage:10 mg/kg; 30 mg/kg; 100 mg/kg
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Administration:p.o.; twice at 0 and 24 hours post-infection
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Result:Produced a 3-log reduction in Bacteroides fragilis colony-forming units (cfu) in abscesses at 10 mg/kg.
Achieved complete sterilization of abscesses at 100 mg/kg.
Chemical Information
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No. CAS 56302-13-7
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Peso molecular 289.27
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Fòrmula C8H11N5O5S
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SMILES
O=C1N(CCN1S(=O)(C)=O)C2=NC=C(N2C)[N+]([O-])=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Zahoor A, et al. Satranidazole: mechanism of action on DNA and structure-activity correlations. J Antimicrob Chemother. 1986;18(1):17-25. [Content Brief]
[2]. Gowrishankar R, et al. Satranidazole: experimental evaluation of activity against anaerobic bacteria in vitro and in animal models of anaerobic infection. J Antimicrob Chemother. 1985;15(4):463-470. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Satranidazole Related Classifications
HY-119475 Related Classifications
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Keywords
- Satranidazole
- 56302-13-7
- Bacterial
- Insecticide
- DNA/RNA Synthesis
- Entamoeba histolytica
- Trichomonas foetus
- Propionobacterium acnes
- Gram-negative anaerobic bacteria
- bacteriophage φX174 DNA
- rodent models
- Trichomonas vaginalis
- Fusobacterium necrophorum
- Gram-positive anaerobic bacteria
- Bacteroides fragilis
- Inhibitor
- inhibitor
- inhibit