Triptriolide
Based on 1 Customer Validation
Triptriolide inhibits Puromycin aminonucleoside PAN (HY-15695)-induced apoptosis in mouse podocytes through regulation of Bcl-2 family proteins and inhibition of Caspase-3. Triptriolide promotes the cell survival, protects and restores the podocyte function through activation of TAK1-NF-κB signaling pathway and upregulation of podocin.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 137131-18-1
- Fòrmula: C20H26O7
- Peso molecular:378.42
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BGC-823 | IC50 |
>10 μM
Compound: 8d
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Cytotoxicity against human BGC-823 cells by MTT assay
Cytotoxicity against human BGC-823 cells by MTT assay
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[PMID: 33289552] |
| HCT-116 | IC50 |
>10 μM
Compound: 8d
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Cytotoxicity against human HCT-116 cells by MTT assay
Cytotoxicity against human HCT-116 cells by MTT assay
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[PMID: 33289552] |
| HepG2 | IC50 |
>10 μM
Compound: 8d
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Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
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[PMID: 33289552] |
Chemical Information
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No. CAS 137131-18-1
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Appearance Solid
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Peso molecular 378.42
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Fòrmula C20H26O7
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Color White to off-white
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SMILES
C[C@@]12[C@@]34[C@]5([C@@H]([C@@](O)([C@@H]([C@]3([H])O4)O)C(C)C)O)[C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Triptriolide Related Classifications
HY-N15315 Related Classifications
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