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TX1-85-1

3 Cited Publications
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Based on 3 publication(s) in Google Scholar

TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.

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  • Pureza: 99.65%
  • No. CAS: 1603845-32-4
  • Fòrmula: C32H36N8O3
  • Peso molecular:580.68
  • Almacenamiento:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • TX1-85-1 Chemical Structure
    TX1-85-1 Chemical Structure
  • Experimental Validation Results for TX1-85-1
  • Experimental Validation Results for TX1-85-1
  • Experimental Validation Results for TX1-85-1
No. CAS: 1603845-32-4
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • TX1-85-1 Chemical Structure
    TX1-85-1 Chemical Structure
    1/16
  • 1/16

    TX1-85-1 purchased from MedChemExpress. Usage Cited in: Sci Adv. 2026 Apr 3;12(14):eady4536. [Abstract]

    Customer Validation
     Western blot of neural crest, pigment, NF-κB pathway, and HER2/HER3 pathway genes upon treatment with TNF-α, pan-HER inhibitors (afatinib and TX1-85-1), or combinations in OMM-1 and SNMM-SDC cells. Cells were treated with TNF-α (25 ng/ml, 72 hours) and then afatinib (5 μM) or TX1-85-1 (5 μM, 24 hours).

  • 1/16

    TX1-85-1 purchased from MedChemExpress. Usage Cited in: Sci Adv. 2026 Apr 3;12(14):eady4536. [Abstract]

    Customer Validation
     Dose-response curves showing increased TX1-85-1 (0, 2, 4, 6, 8, 10 μM) sensitivity in OMM-1 after TNF-α treatment.

  • 1/16

    TX1-85-1 purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2024 Jan 31.

    Customer Validation
     FACS analysis of lipid peroxidation via BODIPY™ 581/591 C11 staining. The upper panel summarizes data from ≥3 independent experiments, while the lower panel displays representative histograms. Cells were incubated for 48 h with TX1-85-1 (5 µM for Hs746T, MKN7, MKN45, and NCI-N87 cells; 3 µM for MKN74 cells).

  • TX1-85-1