Zarutatug
Based on 1 Customer Validation
Zarutatug (TORL-3-600 antibody) is an IgG1κ humanized antibody targeting cadherin 17 (CDH17). It selectively binds to cell-surface CDH17, triggering endocytosis and trafficking to lysosomes. Zarutatug can be used to construct ADCs, such as TORL-3-600.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.11%
- No. CAS: 3038456-02-6
- Peso molecular:145.2 kDa
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Almacenamiento:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
Descripciòn
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CDH17/Cadherin-17
In Vitro
TORL-3-600 induces tumor regression and inhibits tumor growth in CDH17-positive colorectal cancer, gastric cancer and pancreatic cancer models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
AAI13465.1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Cadherin-17 Protein, Human can bind Zarutatug. The EC50 for this effect is 447.5 ng/mL.
Chemical Information
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No. CAS 3038456-02-6
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Appearance Liquid
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Peso molecular 145.2 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
TORL-3-600 antibody
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)