Ethylmalonic acid-d5
Based on 1 Customer Validation
Ethylmalonic acid-d5 is the deuterium labeled Ethylmalonic acid (HY-34740). Ethylmalonic acid is a short-chain organic dicarboxylic acid. Ethylmalonic acid synergistically induces mitochondrial permeability transition (MP) with Ca2+, inhibits Mi-CK, and disrupts mitochondrial energy metabolism. Ethylmalonic acid can be used in the research of SCADD, EE and other genetic metabolic diseases characterized by EMA accumulation.
For research use only. We do not sell to patients.
- Purity: 98.09%
- CAS No.: 66311-22-6
- Formula: C5H3D5O4
- Molecular Weight:137.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 66311-22-6
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Unlabeled Cas 601-75-2
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Appearance Solid
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Molecular Weight 137.15
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Formula C5H3D5O4
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Color White to off-white
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SMILES
O=C(O)C(C([2H])([2H])C([2H])([2H])[2H])C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (1822.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Cecatto C, et al. Ethylmalonic acid induces permeability transition in isolated brain mitochondria. Neurotox Res. 2014 Aug;26(2):168-78. [Content Brief]
[3]. Leipnitz G, et al. Ethylmalonic acid inhibits mitochondrial creatine kinase activity from cerebral cortex of young rats in vitro. Neurochem Res. 2003 May;28(5):771-7. [Content Brief]
[4]. Schuck PF, et al. Promotion of lipid and protein oxidative damage in rat brain by ethylmalonic acid. Neurochem Res. 2010 Feb;35(2):298-305. [Content Brief]
[5]. Schuck PF, et al. Brain and muscle redox imbalance elicited by acute ethylmalonic acid administration. PLoS One. 2015 May 26;10(5):e0126606. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.2913 mL | 36.4564 mL | 72.9129 mL | 182.2822 mL |
| 5 mM | 1.4583 mL | 7.2913 mL | 14.5826 mL | 36.4564 mL | |
| 10 mM | 0.7291 mL | 3.6456 mL | 7.2913 mL | 18.2282 mL | |
| 15 mM | 0.4861 mL | 2.4304 mL | 4.8609 mL | 12.1521 mL | |
| 20 mM | 0.3646 mL | 1.8228 mL | 3.6456 mL | 9.1141 mL | |
| 25 mM | 0.2917 mL | 1.4583 mL | 2.9165 mL | 7.2913 mL | |
| 30 mM | 0.2430 mL | 1.2152 mL | 2.4304 mL | 6.0761 mL | |
| 40 mM | 0.1823 mL | 0.9114 mL | 1.8228 mL | 4.5571 mL | |
| 50 mM | 0.1458 mL | 0.7291 mL | 1.4583 mL | 3.6456 mL | |
| 60 mM | 0.1215 mL | 0.6076 mL | 1.2152 mL | 3.0380 mL | |
| 80 mM | 0.0911 mL | 0.4557 mL | 0.9114 mL | 2.2785 mL | |
| 100 mM | 0.0729 mL | 0.3646 mL | 0.7291 mL | 1.8228 mL |
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