Ferroptosis-IN-7
Based on 1 Customer Validation
Ferroptosis-IN-7(Compound 26) is a ferroptosis inhibitor which can restore cell viability, reduce iron accumulation and scavenge reactive oxygen species. Ferroptosis-IN-7 can be used for vascular diseases research.
For research use only. We do not sell to patients.
- Purity: 99.40%
- CAS No.: 3063813-06-6
- Formula: C32H40N4O3S
- Molecular Weight:560.75
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Aging Compound Library
HY-L034
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Anti-Cardiovascular Disease Compound Library
HY-L046
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Ferroptosis Compound Library
HY-L051
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Lactylation Compound Library
HY-L249
Biological Activity
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Cell Line
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Type | Value | Description | References |
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| HUVEC | EC50 |
0.5 μM
Compound: 26
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Anti-ferroptosis activity in HUVEC cells assessed as inhibition of erastin-induced ferroptosis by measuring lethality suppression incubated for 24 hrs by SRB assay
Anti-ferroptosis activity in HUVEC cells assessed as inhibition of erastin-induced ferroptosis by measuring lethality suppression incubated for 24 hrs by SRB assay
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[PMID: 38608329] |
Ferroptosis-IN-7 (10 μM, 24 h) rescues cell viability from 10 μM Erastin (HY-15763) and reduces iron and ROS accumulation, maintain mitochondrial membrane potential, increase GSH levels, decrease LPO and MDA content, and upregulate GPX4 expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3063813-06-6
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Appearance Solid
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Molecular Weight 560.75
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Formula C32H40N4O3S
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Color White to off-white
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SMILES
O=C(N1CCN(CC2=CC=C(S(C)(=O)=O)C=C2)CC1)C3=CC=C(NC4CCCCC4)C(NCC5=CC=CC=C5)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (178.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7833 mL | 8.9166 mL | 17.8333 mL | 44.5831 mL |
| 5 mM | 0.3567 mL | 1.7833 mL | 3.5667 mL | 8.9166 mL | |
| 10 mM | 0.1783 mL | 0.8917 mL | 1.7833 mL | 4.4583 mL | |
| 15 mM | 0.1189 mL | 0.5944 mL | 1.1889 mL | 2.9722 mL | |
| 20 mM | 0.0892 mL | 0.4458 mL | 0.8917 mL | 2.2292 mL | |
| 25 mM | 0.0713 mL | 0.3567 mL | 0.7133 mL | 1.7833 mL | |
| 30 mM | 0.0594 mL | 0.2972 mL | 0.5944 mL | 1.4861 mL | |
| 40 mM | 0.0446 mL | 0.2229 mL | 0.4458 mL | 1.1146 mL | |
| 50 mM | 0.0357 mL | 0.1783 mL | 0.3567 mL | 0.8917 mL | |
| 60 mM | 0.0297 mL | 0.1486 mL | 0.2972 mL | 0.7431 mL | |
| 80 mM | 0.0223 mL | 0.1115 mL | 0.2229 mL | 0.5573 mL | |
| 100 mM | 0.0178 mL | 0.0892 mL | 0.1783 mL | 0.4458 mL |
Ferroptosis-IN-7 Related Classifications
HY-161460 Related Classifications
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