2. Protein Tyrosine Kinase/RTK Apoptosis
  3. FLT3 Apoptosis
  4. Flt-3-IN-1

Flt-3-IN-1 is a potent FLT-3 inhibitor with an IC50 of 0.91 μM. Flt-3-IN-1 can cause leukemia cells G1 phase arrest and induce apoptosis. Flt-3-IN-1 can be used for the research of cancer, such as leukemia.

For research use only. We do not sell to patients.

Flt-3-IN-1

Flt-3-IN-1 Chemical Structure

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Flt-3-IN-1 Related Antibodies

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Description

Flt-3-IN-1 is a potent FLT-3 inhibitor with an IC50 of 0.91 μM. Flt-3-IN-1 can cause leukemia cells G1 phase arrest and induce apoptosis. Flt-3-IN-1 can be used for the research of cancer, such as leukemia[1].

In Vitro

Flt-3-IN-1 exhibits cytotoxicity against HL-60, CCRF-CEM, and MOLT-4 leukemia cell lines with IC50 values of 0.13 μM, 7.50 μM, and 3.65 μM respectively[1].
Flt-3-IN-1 (0.13 μM, 24 h) arrests the cell cycle at the G1 phase and induce apoptosis in HL-60 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flt-3-IN-1 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HL-60 cells
Concentration: 0.13 μM
Incubation Time: 24 h
Result: Increased the proportion of G1 phase cells to 66.59% and decreased the G2/M phase proportion to 4.77%.

Apoptosis Analysis[1]

Cell Line: HL-60 cells
Concentration: 0.13 μM
Incubation Time: 24 h
Result: Showed a total apoptosis rate of 37.7%, including 23.6% early apoptosis and 16.7% late apoptosis.
Upregulated the expression of p53, p27, and p21 proteins in HL-60cells by 4.2-fold, 2.1-fold, and 2.1-fold respectively.
Increased the Bax/Bcl-2 ratio to 0.71 and upregulated caspase-3 expression by 3-fold.
Molecular Weight

482.98

Formula

C24H23ClN4O3S
SMILES

ClC1=CC=C(C2=NN=C(SCC(NC3=CC=C(NC4=CC(CC(C)(C)C4)=O)C=C3)=O)O2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Flt-3-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flt-3-IN-1FLT3ApoptosisCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3LeukemiacancerFLT-3HL-60CCRF-CEMMOLT-4apoptosisInhibitorinhibitorinhibit

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