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Cat. No.: HY-178444

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Flt-3-IN-1

Flt-3-IN-1 is a potent FLT-3 inhibitor with an IC₅₀ of 0.91 μM. Flt-3-IN-1 can cause leukemia cells G1 phase arrest and induce apoptosis. Flt-3-IN-1 can be used for the research of cancer, such as leukemia.

For research use only. We do not sell to patients.

Formula: C₂₄H₂₃ClN₄O₃S
Molecular Weight:482.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Flt-3-IN-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Flt-3-IN-1 exhibits cytotoxicity against HL-60, CCRF-CEM, and MOLT-4 leukemia cell lines with IC₅₀ values of 0.13 μM, 7.50 μM, and 3.65 μM respectively^[1].
Flt-3-IN-1 (0.13 μM, 24 h) arrests the cell cycle at the G1 phase and induce apoptosis in HL-60 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

0.13 μM
Incubation Time:

24 h
Result:

Increased the proportion of G1 phase cells to 66.59% and decreased the G2/M phase proportion to 4.77%.

Apoptosis Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

0.13 μM
Incubation Time:

24 h
Result:

Showed a total apoptosis rate of 37.7%, including 23.6% early apoptosis and 16.7% late apoptosis.
Upregulated the expression of p53, p27, and p21 proteins in HL-60cells by 4.2-fold, 2.1-fold, and 2.1-fold respectively.
Increased the Bax/Bcl-2 ratio to 0.71 and upregulated caspase-3 expression by 3-fold.

Chemical Information

Molecular Weight 482.98
Formula C₂₄H₂₃ClN₄O₃S
SMILES

ClC1=CC=C(C2=NN=C(SCC(NC3=CC=C(NC4=CC(CC(C)(C)C4)=O)C=C3)=O)O2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abdelhameid MK, et al. Design, synthesis and biological screening of some diaryl acetamide derivatives as potential cytotoxic agents on HL-60(TB) cell line. Bioorg Chem. 2025 Oct;165:108999. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

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100 mg

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