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Cat. No.: HY-183624

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Trimer44NMe

Trimer44NMe is a polyamine transport inhibitor (PTI). Trimer44NMe inhibits the polyamine transport of putrescine (Put), spermidine (Spd), and spermine (Spm). Trimer44NMe can be used for research of Pancreatic ductal adenocarcinoma (PDAC).

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CAS No.: 1258530-99-2
Formule: C₃₆H₇₅N₉
Masse moléculaire:634.04

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Please store the product under the recommended conditions in the Certificate of Analysis.

Trimer44NMe Chemical Structure

CAS No.: 1258530-99-2

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
L3.6pl	IC₅₀	50 μM Compound: Trimer44NMe	Cytotoxicity against human L3.6pl cells assessed as reduction in cell growth measured after 72 hrs by CellTiter96 one aqueous solution assay Cytotoxicity against human L3.6pl cells assessed as reduction in cell growth measured after 72 hrs by CellTiter96 one aqueous solution assay	[PMID: 35178189]

In Vitro

Trimer44NMe inhibits the polyamine transport of putrescine (Put), spermidine (Spd), and spermine (Spm) with K_i of 17.4, 2.6, and 0.9 μM, respectively^[2].
Trimer44NMe (72 h) exhibits cytotoxicity against human pancreatic cancer cells (L3.6pl) with a maximum tolerated concentration (MTC) of 3 μM and an IC₅₀ of 50 μM^[2].
Trimer44NMe (3-10 μM, 15 min) inhibits radiolabeled polyamine uptake in L3.6pl cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1258530-99-2
Masse moléculaire 634.04
Formule C₃₆H₇₅N₉
SMILES

CNCCCCNCCCCNCC1=CC(CNCCCCNCCCCNC)=CC(CNCCCCNCCCCNC)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Wang M, et al. Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model Suggests the Existence of Multiple Transport Systems. Med. Sci. 2017, 5, 27.

[2]. Dobrovolskaite A, et al. Development of Polyamine Lassos as Polyamine Transport Inhibitors. ACS Med Chem Lett. 2022 Jan 20;13(2):319-326. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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