ZH25
ZH25 is an ATR kinase inhibitor with antiproliferative activity against ATM-deficient cancer cells. ZH25 induces DNA damage, reduces G2/M phase cell proportion, upregulates γH2AX, Cleaved-Caspase3, and Cleaved-PARP. ZH25 functions as an ATR kinase binding ligand for ATR-PROTAC degrader design. ZH25 can be used for the research of atm-deficient cancer.
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- CAS No.: 3037598-39-0
- Formule: C20H23N5O
- Masse moléculaire:349.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
ZH25 (72 h) inhibits the proliferation of ATM-deficient LoVo cells with an IC50 of 32.8 μM, but has no activity against ATM-proficient HCT116 cells or normal NCM460 cells[1].
ZH25 (72 h) does not inhibit the proliferation of ATM-deficient NCI-H23 or GRANTA-519 cells, with IC50 values >50 μM for both cell lines[1].
ZH25 (10 μM; 72 h) induces a small increase in DNA damage in LoVo cells, and induces less DNA damage than the ATR degrader I-1 at lower concentrations[1].
ZH25 (10 μM; 48 h) induces apoptosis in LoVo cells, and induces less apoptosis than the ATR degrader I-1 at 5 μM[1].
ZH25 (10 μM; 48 h) reduces the proportion of LoVo cells in the G2/M phase[1].
ZH25 (6.25-25 μM; 24 h) slightly upregulates DNA damage and apoptosis markers in LoVo cells, with weaker activity than the ATR degrader I-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3037598-39-0
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Masse moléculaire 349.43
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Formule C20H23N5O
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SMILES
C[C@@H]1COCCN1C2=NC(C3=CC=CC4=C3C=CN4)=NC5=C2CCNC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZH25 Related Classifications
HY-184294 Related Classifications
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