Furanone C-30
Based on 1 publication(s) in Google Scholar
Furanone C-30 is a quorum sensing inhibitor. Furanone C-30 can effectively inhibit bacterial biofilm formation by S. mutans and its luxSmutant strain.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 247167-54-0
- Formula: C5H2Br2O2
- Molecular Weight:253.88
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Furanone C-30
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Biological Activity
Bacterial biofilm[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L-428 | IC50 |
3.05 μM
Compound: 1; Br-Furanone
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Cytotoxicity against human L428 cells after 48 h by XTT assay
Cytotoxicity against human L428 cells after 48 h by XTT assay
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[PMID: 28526369] |
| L-428 | IC50 |
3.05 μM
Compound: 1; Br-Furanone
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Cytotoxicity against human L428 cells after 48 by XTT assay
Cytotoxicity against human L428 cells after 48 by XTT assay
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[PMID: 28526369] |
| L-428 | IC50 |
5.16 μM
Compound: 1; Br-Furanone
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Cytotoxicity against human L428 cells after 24 by XTT assay
Cytotoxicity against human L428 cells after 24 by XTT assay
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[PMID: 28526369] |
The difference in the OD590 values is statistically significant at concentrations of 2.0 μg/mL and 4.0 μg/mL compared with the control group. Furanone C-30 (2.0 μg/mL and 4.0 μg/mL) can inhibit biofilm formation by S. mutans and its luxS mutant strain, although it does not affect the bacterial growth rate itself[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Streptococcus mutans UA159 and its luxS mutant strain
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Concentration:0.0, 2.0 and 4.0 μg/mL
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Incubation Time:24 hours
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Result:When 2.0 μg/mL was added, the OD590 values for S. mutans and its luxS mutant strain decreased by 42.7% and 40.8%, respectively. When the concentration was increased to 4.0 μg/mL, a decrease of 61.5% and 60.3%, respectively.
Chemical Information
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CAS No. 247167-54-0
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Appearance Solid
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Molecular Weight 253.88
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Formula C5H2Br2O2
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Color White to off-white
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SMILES
O=C(C=C/1Br)OC1=C/Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Microbiol Spectr
Combining Colistin with Furanone C-30 Rescues Colistin Resistance of Gram-Negative Bacteria in Vitro and in Vivo. [Abstract]2021 Dec 22;9(3):e0123121. PMID: 34730415
Solvent & Solubility
DMSO : 100 mg/mL (393.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (556 KB)
- English - EN (556 KB)
- Français - FR (556 KB)
- Deutsch - DE (556 KB)
- Norwegian - NO (556 KB)
- Español - ES (556 KB)
- Swedish - SV (556 KB)
- Italian - IT (556 KB)
- Korean - KR (556 KB)
- Portuguese - PT (556 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9389 mL | 19.6943 mL | 39.3887 mL | 98.4717 mL |
| 5 mM | 0.7878 mL | 3.9389 mL | 7.8777 mL | 19.6943 mL | |
| 10 mM | 0.3939 mL | 1.9694 mL | 3.9389 mL | 9.8472 mL | |
| 15 mM | 0.2626 mL | 1.3130 mL | 2.6259 mL | 6.5648 mL | |
| 20 mM | 0.1969 mL | 0.9847 mL | 1.9694 mL | 4.9236 mL | |
| 25 mM | 0.1576 mL | 0.7878 mL | 1.5755 mL | 3.9389 mL | |
| 30 mM | 0.1313 mL | 0.6565 mL | 1.3130 mL | 3.2824 mL | |
| 40 mM | 0.0985 mL | 0.4924 mL | 0.9847 mL | 2.4618 mL | |
| 50 mM | 0.0788 mL | 0.3939 mL | 0.7878 mL | 1.9694 mL | |
| 60 mM | 0.0656 mL | 0.3282 mL | 0.6565 mL | 1.6412 mL | |
| 80 mM | 0.0492 mL | 0.2462 mL | 0.4924 mL | 1.2309 mL | |
| 100 mM | 0.0394 mL | 0.1969 mL | 0.3939 mL | 0.9847 mL |
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