G721-0377

G721−0377 binds to purified human CHI3L1 protein with a K_d of 45 μM^[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h incubation) dose-dependently restores pHrodo-Aβ_1-42 uptake in CHI3L1-treated human iPSC-derived astrocytes^[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h cincubation) dose-dependently restores lysosomal proteolytic function (DQ-BSA degradation) in CHI3L1-treated human iPSC-derived astrocytes^[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h incubation) dose-dependently restores lysosomal acidification in CHI3L1-treated human iPSC-derived astrocytes, with significant recovery observed at 25 and 50 μM^[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h cincubation) dose-dependently suppresses CHI3L1 secretion in CHI3L1-treated human iPSC-derived astrocytes^[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h cincubation) dose-dependently suppresses IL-6 secretion in CHI3L1-treated human iPSC-derived astrocytes^[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h cincubation) dose-dependently suppresses CHI3L1-induced NF-κB activation in human iPSC-derived astrocyte^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.