2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Glycosidase NF-κB Interleukin Related
  4. G721-0377

G721-0377 is a CHI3L1 modulator with a human Kd value of 45 μM. G721-0377 binds to CHI3L1 and modulates downstream signaling pathways. G721-0377 suppresses CHI3L1-induced NF-κB activation, decreases secretion of CHI3L1 and IL-6. G721-0377 can be used for the research of Alzheimer's disease.

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G721-0377

G721-0377 Chemical Structure

CAS No. : 946336-44-3

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G721-0377 Related Antibodies

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

G721-0377 is a CHI3L1 modulator with a human Kd value of 45 μM. G721-0377 binds to CHI3L1 and modulates downstream signaling pathways. G721-0377 suppresses CHI3L1-induced NF-κB activation, decreases secretion of CHI3L1 and IL-6. G721-0377 can be used for the research of Alzheimer's disease[1].

IC50 & Target[1]

NF-κB

 

IL-6

 

In Vitro

G721−0377 binds to purified human CHI3L1 protein with a Kd of 45 μM[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h incubation) dose-dependently restores pHrodo-Aβ1-42 uptake in CHI3L1-treated human iPSC-derived astrocytes[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h cincubation) dose-dependently restores lysosomal proteolytic function (DQ-BSA degradation) in CHI3L1-treated human iPSC-derived astrocytes[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h incubation) dose-dependently restores lysosomal acidification in CHI3L1-treated human iPSC-derived astrocytes, with significant recovery observed at 25 and 50 μM[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h cincubation) dose-dependently suppresses CHI3L1 secretion in CHI3L1-treated human iPSC-derived astrocytes[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h cincubation) dose-dependently suppresses IL-6 secretion in CHI3L1-treated human iPSC-derived astrocytes[1].
G721−0377 (10-50 μM; 30 min pre-incubation; followed by 24 h cincubation) dose-dependently suppresses CHI3L1-induced NF-κB activation in human iPSC-derived astrocyte[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

G721-0377 Related Antibodies

ELISA Assay[1]

Cell Line: human iPSC-derived astrocytes treated with recombinant CHI3L1
Concentration: 10 μM; 25 μM; 50 μM
Incubation Time: 30 min pre-incubation; followed by 24 h incubation
Result: Robustly suppressed CHI3L1-induced CHI3L1 and IL-6 secretion in a dose-dependent manner, achieving statistically significant reduction at 10 μM and near-baseline levels at 50 μM, relative to CHI3L1-treated controls.
Molecular Weight

455.53

Formula

C22H25N5O4S
CAS No.
SMILES

CC(C)CC1=C(SCC(NC2=CC=C(C(N)=O)C=C2)=O)C3=C(N=C1)N(C)C(N(C)C3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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G721-0377 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G721-0377946336-44-3GlycosidaseNF-κBInterleukin RelatedNuclear factor-κBNuclear factor-kappaBILIL-6downstream signaling pathwaysmicrosomal clearanceamyloid uptakeAlzheimer's diseaselysosomal proteolysisCHI3L1human iPSC-derived astrocyteslysosomal acidificationInhibitorinhibitorinhibit

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