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Verteporfin

(Synonyms: CL 318952)
286 Cited Publications
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Based on 286 publication(s) in Google Scholar

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation.

For research use only. We do not sell to patients.

  • Purity: 98.15%
  • CAS No.: 129497-78-5
  • Formula: C41H42N4O8
  • Molecular Weight:718.79
  • Storage:

    -20°C, protect from light, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

  • Verteporfin Chemical Structure
    Verteporfin Chemical Structure
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
CAS No.: 129497-78-5
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Verteporfin Chemical Structure
    Verteporfin Chemical Structure
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    Verteporfin purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Jan 13;15(1):202-226. [Abstract]

    Customer Validation
     Verteporfin (0.5 μM; pretreatment for 4 hours followed by 30-minute treatment) inhibits norepinephrine (NE)- or dexmedetomidine (DEX)-induced YAP dephosphorylation (activated state) in AKP tumor cells, restores phosphorylation levels of LATS1 and YAP, and blocks ADRA2A/Gi-mediated YAP signaling pathway activation.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Apr 1;21(1):238. [Abstract]

    Customer Validation
     Verteporfin (13.9 µM; 10 µg/mL; 24 h) decreases the expression of YAP and CDX2 in NSCCs.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Reprod Sci. 2023 Sep;30(9):2715-2727. [Abstract]

    Customer Validation
     Verteporfin (0-5 µM; 24 h) decreases the viability of Ishikawa cells in a concentration-dependent manner (IC50 = 1.345 µM).

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Reprod Sci. 2023 Sep;30(9):2715-2727. [Abstract]

    Customer Validation
     Verteporfin (0.5, 1, 2 µM) decreases the expression of anti-apoptotic marker B cell leukemia 2 (Bcl2), while increases the expression of pro-apoptotic protein Bcl2-associated X protein (Bax) in Ishikawa cells, in a concentration-dependent manner.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Jun;32(6):543-554. [Abstract]

    Customer Validation
     Survival of mice with striatal GL261 tumor injection with or without RT, saline plus laser treatment, or Verteporfin (Visudyne; 2 mg/mL; 5 μL was injected into the cisterna magna; 15 min) plus laser treatment.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2022 Jul;25(7):849-864. [Abstract]

    Customer Validation
     Verteporfin (1 µM)-treated animals exposed to 640 nm in the head exhibits less mrc1a+ cells in the brain compared to non-photoactivated control animals.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Oct 5;13(1):5871. [Abstract]

    Customer Validation
     Mice are injected with either Verteporfin (VP; 100 mg/kg) or vehicle (corn oil) from the postnatal 7 days at 3-day intervals for 14 days. The immunohistochemical assay shows that the expression of TFRC and COX2 is higher in Bnc1tr/tr control mouse ovaries than in Bnc1+/+ control mouse ovaries. Intriguingly, VP treatment partially rescues TFRC and COX2 expression in Bnc1tr/tr mouse ovaries.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153. [Abstract]

    Customer Validation
     The expression levels of Hippo-YAP signaling downstream regenerative genes (Ctgf, Ankrd1 and Cyr61) are effectively inhibited by Verteporfin (VP; 100 µM) compared to their expression in the blank control group.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153. [Abstract]

    Customer Validation
     Compared to cell viability in the vehicle control group, Verteporfin (VP; 100 µM) markedly impairs cell viability assayed by JC-1 staining and CCK-8.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153. [Abstract]

    Customer Validation
     Compared to cell viability in the vehicle control group, Verteporfin (VP; 100 µM) markedly impairs cell viability assayed by JC-1 staining and CCK-8.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153. [Abstract]

    Customer Validation
     The protective effects of TNIP3 against cell inflammation and cell death were largely abolished by Verteporfin (VP; 100 µM) administration.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Cell Res. 2020 Mar;30(3):229-243. [Abstract]

    Customer Validation
     The representative images of dCLNs and sCLNs 2 weeks after striatal injection of GL261 or B16 cells into mice treated with Vehicle + Laser or =Verteporfin (Visudyne; 2 mg/mL; 5 μL was injected into the cisterna magna; 15 min) + Laser.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Verteporfin displays a complete suppression of viral CPE at 0.31 µM. Viral N protein expression in infected Vero E6 cells was assessed by immunofluorescence.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Protoporphyrin IX and Verteporfin effectively prevent SARS-CoV-2 infection in the mouse model expressing human ACE2. Much fewer cells expressed viral N protein in the Protoporphyrin IX and Verteporfin (20 µM) groups compared to the DMSO group.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Verteporfin (0.31 µM) inhibits N protein expression in SARS-CoV-2-infected Vero E6 cells.​

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Antiviral effect and cell cytotoxicity of protoporphyrin IX and verteporfin. The viral RNA production in the supernatant of infected Vero E6 cells was quantified with qRT-PCR. The value at each compound concentration was presented relative to that at zero compound concentration that was set as 100% (blue).

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2019 Sep 16;36(3):302-318.e7. [Abstract]

    Customer Validation
     Combined treatment of GFAP-Ptch tumor cells with Verteporfin (VP; 24 hours) and CD532 additively decreases proliferation of ZIC1+ tumor cells relative to individual treatments.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Mol Cell. 2019 Jan 3;73(1):7-21.e7. [Abstract]

    Customer Validation
     Control low metastatic MDA-MB-231 cells or cells overexpressing OTUB2-WT, pretreated with or without Verteporfin (VP, 10 µM) are intracardially injected into nude mice.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Mol Immunol. 2019 Mar:107:29-40. [Abstract]

    Customer Validation
     Col1a1 and α-SMA protein levels are analyzed in cells treated with VP.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Mol Immunol. 2019 Mar:107:29-40. [Abstract]

    Customer Validation
     Col1a1 and α-SMA protein levels are analyzed in cells treated with VP.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2018 Dec 11:12:489. [Abstract]

    Customer Validation
     OECs are treated with vehicle (0.1% DMSO), Y27632 (10 μM) or verteporfin (5 μM) for 24 h and performed WB analysis.

  • Verteporfin