Antimalarial agent 10
Antimalarial agent 10 (Compound 17b) is an aminoalcohol quinoline compound. Antimalarial agent 10 is an antimalarial agent with IC50 values of 14.9 nM and 11.0 nM against respectively Pf3D7 and PfW2 and a selectivity index higher than 770 whatever the cell line is.
For research use only. We do not sell to patients.
- CAS No.: 2747280-03-9
- Formula: C23H22F6N2O2
- Molecular Weight:472.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
47.3 μM
Compound: 17b
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Cytotoxicity against Chinese hamster CHO cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against Chinese hamster CHO cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
|
[PMID: 34782182] |
| HepG2 | IC50 |
11.6 μM
Compound: 17b
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 34782182] |
| HFF | IC50 |
44.2 μM
Compound: 17b
|
Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 34782182] |
| THP-1 | IC50 |
16.2 μM
Compound: 17b
|
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 34782182] |
Chemical Information
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CAS No. 2747280-03-9
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Molecular Weight 472.42
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Formula C23H22F6N2O2
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SMILES
FC(F)(C1=CC=CC2=C1N=C(C(F)(F)F)C=C2[C@H](O)CN[C@H](COC)CC3=CC=CC=C3)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)