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Batoclimab

(Synonyms: RVT-1401; HBM9161; IMVT-1401)
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Based on 1 Customer Validation

Batoclimab (RVT-1401) is a fully humanized IgG1 monoclonal antibody targeting FcRn. Batoclimab has high affinity for the IgG-binding site on FcRn. By competitively binding to the IgG binding site on FcRn, Batoclimab blocks FcRn-mediated recycling of IgG, resulting in enhanced degradation and subsequent reductions in IgG levels. Batoclimab can be used in the research of autoimmune diseases such as myasthenia gravis and thyroid eye disease.

For research use only. We do not sell to patients.

  • Purity: 99.89%
  • CAS No.: 2187430-05-1
  • Molecular Weight:143.43 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Batoclimab
  • Experimental Validation Results for Batoclimab
  • Experimental Validation Results for Batoclimab
  • Batoclimab Chemical Structure
    Batoclimab Chemical Structure
CAS No.: 2187430-05-1
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Batoclimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 lambda2

  • 1/16

    Immobilized FCRN-B2M Protein, Human (HEK293, His, HY-P70601) can bind Batoclimab. The EC50 for this effect is 97.79 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 THP-1 cells with Batoclimab (HY-P99009, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2, Isotype Control (HY-P990096) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Batoclimab Chemical Structure
    1/16
  • Batoclimab
  • Immobilized FCRN-B2M Protein, Human (HEK293, His, HY-P70601) can bind Batoclimab. The EC50 for this effect is 97.79 ng/mL.
  • Flow cytometric analysis of 1.5×106 THP-1 cells with Batoclimab (HY-P99009, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2, Isotype Control (HY-P990096) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Human IgG1 lambda2