(-)-Integerrimine
(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila.
For research use only. We do not sell to patients.
- CAS No.: 480-79-5
- Formula: C18H25NO5
- Molecular Weight:335.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A204 | IC50 |
120 μg/mL
Compound: 2
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Cytotoxicity against human A204 cells after 24 hrs by soft agar colony forming assay
Cytotoxicity against human A204 cells after 24 hrs by soft agar colony forming assay
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[PMID: 3210016] |
| CHO | EC50 |
>100 μg/mL
Compound: 4
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Toxicity against Cricetulus griseus CHO (Chinese hamster ovary) cell by MTT assay
Toxicity against Cricetulus griseus CHO (Chinese hamster ovary) cell by MTT assay
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10.1016/jbse.2007.08.015 |
| Sf9 | EC50 |
>100 μg/mL
Compound: 4
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Toxicity against Spodoptera frugiperda (fall armyworm) Sf9 cells by MTT assay
Toxicity against Spodoptera frugiperda (fall armyworm) Sf9 cells by MTT assay
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10.1016/jbse.2007.08.015 |
(-)-Integerrimine (0.00625-0.05 mM) also must have mutagenic activity in somatic cells of Drosophila. (-)-Integerrimine in general requires cytochrome P450-dependent metabolic activation to exhibit genotoxic activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 480-79-5
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Molecular Weight 335.39
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Formula C18H25NO5
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SMILES
O=C1O[C@@]2([H])[C@]3([H])N(CC=C3COC([C@](O)([C@@H](C/C1=C\C)C)C)=O)CC2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. V R Campesato, et al. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environ Mol Mutagen. 1997;29(1):91-7. [Content Brief]
[2]. Walber Toma, et al. Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. Can J Physiol Pharmacol. 2004 May;82(5):319-25. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(-)-Integerrimine Related Classifications
HY-122772 Related Classifications
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