ProINDY
Based on 1 Customer Validation
ProINDY, a prodrug of INDY (HY-108476), is a DYRK1A and DYRK1B inhibitor. ProINDY effectively recovers Xenopus embryos from head malformation induced by Dyrk1A overexpression.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 719277-30-2
- Formula: C14H15NO3S
- Molecular Weight:277.34
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-108476
INDY
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HY-A0063
Tipiracil hydrochloride
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HY-102071
KIN59
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HY-108476R
INDY (Standard)
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HY-100464
tBID
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HY-115677
ILK-IN-3
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HY-34222
7-Deazaguanine
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HY-A0063R
Tipiracil hydrochloride (Standard)
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HY-102071R
KIN59 (Standard)
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HY-13455A
LDN-192960 hydrochloride
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HY-142295A
GNF2133 hydrochloride
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HY-100464R
tBID (Standard)
Biological Activity
In the cultured cells overexpressing Dyrk1A or xDyrk1A, ProINDY inhibits the phosphorylation of Thr212 of the tau-protein. ProINDY also rescues the NFAT pathway in Dyrk1A-overexpressing cells, confirming the identical Dyrk1A-inhibitory effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 719277-30-2
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Appearance Solid
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Molecular Weight 277.34
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Formula C14H15NO3S
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Color Off-white to light yellow
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SMILES
CC(/C=C1SC2=CC=C(OC(C)=O)C=C2N\1CC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (360.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6057 mL | 18.0284 mL | 36.0568 mL | 90.1421 mL |
| 5 mM | 0.7211 mL | 3.6057 mL | 7.2114 mL | 18.0284 mL | |
| 10 mM | 0.3606 mL | 1.8028 mL | 3.6057 mL | 9.0142 mL | |
| 15 mM | 0.2404 mL | 1.2019 mL | 2.4038 mL | 6.0095 mL | |
| 20 mM | 0.1803 mL | 0.9014 mL | 1.8028 mL | 4.5071 mL | |
| 25 mM | 0.1442 mL | 0.7211 mL | 1.4423 mL | 3.6057 mL | |
| 30 mM | 0.1202 mL | 0.6009 mL | 1.2019 mL | 3.0047 mL | |
| 40 mM | 0.0901 mL | 0.4507 mL | 0.9014 mL | 2.2536 mL | |
| 50 mM | 0.0721 mL | 0.3606 mL | 0.7211 mL | 1.8028 mL | |
| 60 mM | 0.0601 mL | 0.3005 mL | 0.6009 mL | 1.5024 mL | |
| 80 mM | 0.0451 mL | 0.2254 mL | 0.4507 mL | 1.1268 mL | |
| 100 mM | 0.0361 mL | 0.1803 mL | 0.3606 mL | 0.9014 mL |
ProINDY Related Classifications
HY-108475 Related Classifications
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