TP-030-2
Based on 1 Customer Validation
TP-030-2, a chemical probe, is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM).
For research use only. We do not sell to patients.
- Purity: 98.17%
- CAS No.: 2095514-84-2
- Formula: C23H21BrN4O3
- Molecular Weight:481.34
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
TP-030-2 shows inhibiton in HT29 with IC50=1.3 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2095514-84-2
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Appearance Solid
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Molecular Weight 481.34
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Formula C23H21BrN4O3
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Color Off-white to light yellow
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SMILES
O=C1C2=NN(CC3=CC=CC=C3)C(Br)=C2CCN1[C@@H]4C(N(C5=CC=CC=C5OC4)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (207.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409. [Content Brief]
[2]. https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-030-2
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0775 mL | 10.3877 mL | 20.7753 mL | 51.9383 mL |
| 5 mM | 0.4155 mL | 2.0775 mL | 4.1551 mL | 10.3877 mL | |
| 10 mM | 0.2078 mL | 1.0388 mL | 2.0775 mL | 5.1938 mL | |
| 15 mM | 0.1385 mL | 0.6925 mL | 1.3850 mL | 3.4626 mL | |
| 20 mM | 0.1039 mL | 0.5194 mL | 1.0388 mL | 2.5969 mL | |
| 25 mM | 0.0831 mL | 0.4155 mL | 0.8310 mL | 2.0775 mL | |
| 30 mM | 0.0693 mL | 0.3463 mL | 0.6925 mL | 1.7313 mL | |
| 40 mM | 0.0519 mL | 0.2597 mL | 0.5194 mL | 1.2985 mL | |
| 50 mM | 0.0416 mL | 0.2078 mL | 0.4155 mL | 1.0388 mL | |
| 60 mM | 0.0346 mL | 0.1731 mL | 0.3463 mL | 0.8656 mL | |
| 80 mM | 0.0260 mL | 0.1298 mL | 0.2597 mL | 0.6492 mL | |
| 100 mM | 0.0208 mL | 0.1039 mL | 0.2078 mL | 0.5194 mL |
TP-030-2 Related Classifications
HY-148239 Related Classifications
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