3-aceCA
Based on 1 Customer Validation
3-aceCA is an orally active 3α-O-acetyl cholic acid derivative and monoacylated bile acid. 3-aceCA can be used for the study of gut microbiota-bile acid metabolism and metabolic dysfunction-associated steatohepatitis (MASH).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.45%
- No. CAS: 7432-73-7
- Fòrmula: C26H42O6
- Peso molecular:450.61
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SPF mice (8-week-old; MASH induced by 8-week CDAA-HFD feeding)[1]
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Dosage:10 mg/kg
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Administration:p.o.; 3 times/week; 3 weeks
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Result:Showed no significant beneficial effects on MASH progression.
Failed to reduce liver weight relative to body weight.
Failed to decrease plasma alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels.
Failed to reduce hepatic triglyceride (TG) levels.
Failed to improve hepatic steatosis, inflammation, or fibrosis.
Chemical Information
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No. CAS 7432-73-7
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Appearance Solid
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Peso molecular 450.61
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Fòrmula C26H42O6
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SMILES
O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(O)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)OC(C)=O)([H])C1)C)O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (221.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2192 mL | 11.0961 mL | 22.1921 mL | 55.4804 mL |
| 5 mM | 0.4438 mL | 2.2192 mL | 4.4384 mL | 11.0961 mL | |
| 10 mM | 0.2219 mL | 1.1096 mL | 2.2192 mL | 5.5480 mL | |
| 15 mM | 0.1479 mL | 0.7397 mL | 1.4795 mL | 3.6987 mL | |
| 20 mM | 0.1110 mL | 0.5548 mL | 1.1096 mL | 2.7740 mL | |
| 25 mM | 0.0888 mL | 0.4438 mL | 0.8877 mL | 2.2192 mL | |
| 30 mM | 0.0740 mL | 0.3699 mL | 0.7397 mL | 1.8493 mL | |
| 40 mM | 0.0555 mL | 0.2774 mL | 0.5548 mL | 1.3870 mL | |
| 50 mM | 0.0444 mL | 0.2219 mL | 0.4438 mL | 1.1096 mL | |
| 60 mM | 0.0370 mL | 0.1849 mL | 0.3699 mL | 0.9247 mL | |
| 80 mM | 0.0277 mL | 0.1387 mL | 0.2774 mL | 0.6935 mL | |
| 100 mM | 0.0222 mL | 0.1110 mL | 0.2219 mL | 0.5548 mL |
3-aceCA Related Classifications
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