4-PSQ
4-PSQ is an orally active neuroprotective agent. 4-PSQ possesses both antioxidant and anti-inflammatory activities. 4-PSQ improves cognitive impairment and depressive- and anxiety-like emotional abnormalities in mice by regulating the activity of Na+, K+-ATPase, the NFκB signaling pathway, and the expression of p21. 4-PSQ can be used for the research of neurological diseases.
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- No. CAS: 1415931-33-7
- Fòrmula: C15H10ClNSe
- Peso molecular:318.66
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice with Vincristine (VCR)-induced neurotoxicity (male and female, 60 days old)[1]
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Dosage:1 mg/kg
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Administration:p.o.; daily; days 7 to 16
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Result:Restored short-term and long-term memory impairments induced by vincristine in both sexes.
Normalized depressive-like behavior in both sexes.
Reversed anxiety-like behavior in both sexes.
Counteracted vincristine-induced inhibition of Na+,K+-ATPase activity in the cerebral cortex, spinal cord, and cerebellum of male mice, and in the cerebellum of female mice.
Normalized vincristine-induced increased p21 mRNA expression in the cerebral cortex of female mice.
Normalized vincristine-induced increased NFκB mRNA expression in the cerebral cortex of male mice, and in the spinal cord of male and female mice.
Chemical Information
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No. CAS 1415931-33-7
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Peso molecular 318.66
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Fòrmula C15H10ClNSe
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SMILES
ClC1=CC=C2C([Se]C3=CC=CC=C3)=CC=NC2=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-PSQ Related Classifications
HY-181703 Related Classifications
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