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Referencia número: HY-113455

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9(S)-HODE

(Synonyms: Alpha-dimorphecolic acid)

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9(S)-HODE (Alpha-dimorphecolic acid) is the major active derivative of Linoleic acid (HY-N0729). 9(S)-HODE regulates the expression of miR-361-3p. 9(S)-HODE reduces cancer cell viability and induces cancer cell apoptosis. 9(S)-HODE can be used in the research of acute myeloid leukemia.

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Pureza: 98%
No. CAS: 73543-67-6
Fòrmula: C₁₈H₃₂O₃
Peso molecular:296.44

Almacenamiento:

Solution, -20°C, 2 years

9(S)-HODE Chemical Structure

No. CAS: 73543-67-6

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Descripciòn

IC₅₀ & Target

Human Endogenous Metabolite

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In Vitro

9S-HODE (12.5-25 μM; 12-72 h) significantly downregulates the expression of miR-361-3p in HL-60 cells^[1].
9S-HODE (25 μM; 0-72 h) inhibits the viability of HL-60 cells and induces apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

human acute myeloid leukemia HL-60 cells
Concentration:

25 μM
Incubation Time:

12, 24, 36, 48, 72 h
Result:

Downregulated miR-361-3p expression in a time-dependent manner.
Increased BTG2 mRNA expression.

Apoptosis Analysis^[1]

Cell Line:

human acute myeloid leukemia HL-60 cells
Concentration:

25 μM
Incubation Time:

48 h
Result:

Increased the percentages of early apoptotic (Annexin V+/PI-) and late apoptotic (Annexin V+/PI+) HL-60 cells compared to control.

Chemical Information

No. CAS 73543-67-6
Appearance Liquid
Peso molecular 296.44
Fòrmula C₁₈H₃₂O₃
Color Colorless to light yellow
SMILES

CCCCC/C=C\C=C\[C@@H](O)CCCCCCCC(O)=O
Synonyms

Alpha-dimorphecolic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Solution, -20°C, 2 years

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
SDS (544 KB)
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- Italian - IT (544 KB)
- Korean - KR (544 KB)
- Portuguese - PT (544 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Liu S, et al. Linoleic acid derivatives target miR‐361‐3p/BTG2 to confer anticancer effects in acute myeloid leukemia. Journal of Biochemical and Molecular Toxicology, 2023, 37(11): e23481.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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9(S)-HODE

Ver todos los productos específicos de isoformas Endogenous Metabolite

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9(S)-HODE Related Classifications

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