AF38469
Based on 10 publication(s) in Google Scholar
AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.28%
- No. CAS: 1531634-31-7
- Fòrmula: C15H11F3N2O3
- Peso molecular:324.25
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-115213
SORT-PGRN interaction inhibitor 1Sortilin-Progranulin Interaction Inhibitor -
HY-148650
Sortilin antagonist 1Sortilin Antagonist -
HY-100741
S63845MCL1 Inhibitor -
HY-100579
Ferrostatin-1Ferroptosis Inhibitor -
HY-103389
1-AminobenzotriazoleCytochrome P450 Inhibitor -
HY-10219
RapamycinmTOR Inhibitor -
HY-P0251
Neurotensin(8-13)Neurotensin Receptor Agonist -
HY-W011689
6PPDAntioxidant Agent -
HY-D0718
Nile RedHydrophobic Fluorescent Stain -
HY-107664
SR 142948NT Antagonist -
HY-110155
LM11A-31 dihydrochlorideproNGF Antagonist -
HY-124673
AF40431Sortilin Ligand
Publications Citing Use of MedChemExpress (MCE) AF38469
More- Cell Death Dis. 2019 Feb 27;10(3):208. [Abstract]
- Cell Commun Signal. 2021 Nov 15;19(1):112. [Abstract]
- J Neuroinflammation. 2025 Mar 7;22(1):68. [Abstract]
- Breast Cancer Res. 2018 Nov 20;20(1):137. [Abstract]
- Int J Mol Sci. 2023 Jan 19;24(3):2030. [Abstract]
- Am J Pathol. 2020 Sep;190(9):1931-1942. [Abstract]
- Cancers (Basel). 2023 Dec 8;15(24):5757. [Abstract]
- Cancers (Basel). 2023 Apr 27;15(9):2514. [Abstract]
- bioRxiv. 2026 May 12.
- bioRxiv. 2025 March 11.
Customer Validation & Images
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WB
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Cell Migration/Invasion Assay
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Cell Migration/Invasion Assay
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WB
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Actividad biológica
Descripciòn
IC50 & Target
IC50:330 nM (Sortilin)[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1531634-31-7
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Appearance Solid
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Peso molecular 324.25
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Fòrmula C15H11F3N2O3
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Color Off-white to light yellow
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SMILES
O=C(NC1=CC=CC(C)=N1)C2=CC=C(C(F)(F)F)C=C2C(O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (10)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
Sortilin promotes glioblastoma invasion and mesenchymal transition through GSK-3β/β-catenin/twist pathway. [Abstract]2019 Feb 27;10(3):208. PMID: 30814514
AF38469 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Feb 27;10(3):208. [Abstract]
AF38469 (400 nM; 24 h) impaired the migratory capabilities U87 and A172 cell lines.
AF38469 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Feb 27;10(3):208. [Abstract]
AF38469 (400 nM; 24 h) significantly attenuated the invasive capacities of U87 and A172 cell lines.
AF38469 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Feb 27;10(3):208. [Abstract]
AF38469 (AF; 400 nM; 24 h) reduced the protein expression of N-cadherin, vimentin, and MMP-9 in U87 and A172 cell lines.
AF38469 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Feb 27;10(3):208. [Abstract]
AF38469 (AF; 400 nM; 24 h) decreased the protein expression of p-GSK-3β, β-catenin, and Twist in both U87 and A172 cells.
AF38469 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Feb 27;10(3):208. [Abstract]
AF38469 (AF38; 0, 100, 200, 400, 8000, 1600 nM; 0, 2, 4, 6, 8, 16, 24 h) decreased the protein expression of p-GSK-3β, β-catenin, and Twist in a dose- and time-dependent manner in U87 cells.
AF38469 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Feb 27;10(3):208. [Abstract]
AF38469 (0.1 mg/kg; i.p.; daily for 21 days) showed the tumor volume of subcutaneous GBM was much smaller compared with the control group.
AF38469 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Feb 27;10(3):208. [Abstract]
AF38469 (0.1 mg/kg; i.p.; daily for 21 days) decreased the activation of the GSK-3β/β-catenin/twist axis in tumor tissues and increased T-cadherin expression, while decreasing the levels of N-cadherin, vimentin, and MMP-9 in subcutaneous tumor tissues.
AF38469 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Feb 27;10(3):208. [Abstract]
AF38469 (0.1 mg/kg; i.p.; daily for 21 days) showed that the tumor margin of the AF38469 group was clearer and smoother than that of the DMSO group, suggesting that AF38469 suppresses the invasive capacity of intracranial glioblastoma.
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Cell Commun Signal
2021 Nov 15;19(1):112. PMID: 34781973 -
J Neuroinflammation
Microglial progranulin differently regulates hypothalamic lysosomal function in lean and obese conditions via cleavage-dependent mechanisms. [Abstract]2025 Mar 7;22(1):68. PMID: 40055725 -
Breast Cancer Res
Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion. [Abstract]2018 Nov 20;20(1):137. PMID: 30454027
AF38469 purchased from MedChemExpress. Usage Cited in: Breast Cancer Res. 2018 Nov 20;20(1):137. [Abstract]
Immunohistochemical analyses of the GRN A- and AF38469-treated groups of MDA-MB 231 luc xenografts with skin is performed using Ki67 and haematoxylin staining.
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Int J Mol Sci
Impact of Enniatin B and Beauvericin on Lysosomal Cathepsin B Secretion and Apoptosis Induction. [Abstract]2023 Jan 19;24(3):2030. PMID: 36768354 -
Am J Pathol
The Membrane Protein Sortilin Can Be Targeted to Inhibit Pancreatic Cancer Cell Invasion. [Abstract]2020 Sep;190(9):1931-1942. PMID: 32526166
AF38469 purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2020 Sep;190(9):1931-1942. [Abstract]
Western blot detection of phosphorylation of FAK (Tyr925), FAK (Tyr397) and FAK (Tyr576/577) in the treatment with AF38469. The phosphorylation of residue Tyr925 of FAK is decreased in sortilin-inhibited compared to NT control.
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Cancers (Basel)
Interleukin-6 Induces Stem Cell Propagation through Liaison with the Sortilin-Progranulin Axis in Breast Cancer. [Abstract]2023 Dec 8;15(24):5757. PMID: 38136303 -
Cancers (Basel)
2023 Apr 27;15(9):2514. PMID: 37173980 -
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Solvente y solubilidad
In Vitro:
DMSO : ≥ 43 mg/mL (132.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.0840 mL | 15.4202 mL | 30.8404 mL | 77.1010 mL |
| 5 mM | 0.6168 mL | 3.0840 mL | 6.1681 mL | 15.4202 mL | |
| 10 mM | 0.3084 mL | 1.5420 mL | 3.0840 mL | 7.7101 mL | |
| 15 mM | 0.2056 mL | 1.0280 mL | 2.0560 mL | 5.1401 mL | |
| 20 mM | 0.1542 mL | 0.7710 mL | 1.5420 mL | 3.8551 mL | |
| 25 mM | 0.1234 mL | 0.6168 mL | 1.2336 mL | 3.0840 mL | |
| 30 mM | 0.1028 mL | 0.5140 mL | 1.0280 mL | 2.5700 mL | |
| 40 mM | 0.0771 mL | 0.3855 mL | 0.7710 mL | 1.9275 mL | |
| 50 mM | 0.0617 mL | 0.3084 mL | 0.6168 mL | 1.5420 mL | |
| 60 mM | 0.0514 mL | 0.2570 mL | 0.5140 mL | 1.2850 mL | |
| 80 mM | 0.0386 mL | 0.1928 mL | 0.3855 mL | 0.9638 mL | |
| 100 mM | 0.0308 mL | 0.1542 mL | 0.3084 mL | 0.7710 mL |
AF38469 Related Classifications
HY-12802 Related Classifications
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