GTx-007
Based on 4 publication(s) in Google Scholar
GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.61%
- No. CAS: 401900-40-1
- Fòrmula: C19H18F3N3O6
- Peso molecular:441.36
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-13273
OstarineSARMs -
HY-14383
VosilasarmAndrogen Receptor Modulator -
HY-13981
LigandrolAndrogen Receptor Agonist -
HY-14249
BicalutamideAndrogen Receptor Inhibitor -
HY-100186
GSK-2881078Androgen Receptor Modulator -
HY-112257
S-23Selective Androgen Receptor Modulator -
HY-16985
DarolutamideAndrogen Receptor Antagonist -
HY-15194
DimethylcurcuminAndrogen Receptor Inhibitor -
HY-114530
LY2452473Androgen Receptor Modulator -
HY-10561
RU 58841Androgen Receptor Antagonist -
HY-16079
AZD3514AR Inhibitor -
HY-112256
ACP-105Androgen Receptor Modulator
Publications Citing Use of MedChemExpress (MCE) GTx-007
More
Actividad biológica
Descripciòn
In Vivo
GTx-007 significantly increased uterine expression of Wnt4 and Wnt7a[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female C57BL/6J mice[2].
-
Dosage:0.5 mg/mouse.
-
Administration:Seven daily subcutaneous injections.
-
Result:Resulted in a highly heterogeneous pattern of AR expression in all compartments, with a significant increase of AR-positive cells in the luminal epithelium compared to VC.
Had approximately ten glands per uterine cross-section within an endometrium, with a compact stroma, consistent with overall endogenous steroid depletion.
Did not detect any impact of GTx-007 on body weight.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 401900-40-1
-
Appearance Solid
-
Peso molecular 441.36
-
Fòrmula C19H18F3N3O6
-
Color Light yellow to yellow
-
SMILES
O=C([C@@](O)(COC1=CC=C(C=C1)NC(C)=O)C)NC2=CC=C(C(C(F)(F)F)=C2)[N+]([O-])=O
-
Synonyms
S-4
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
-
Journal Impact Factor
-
Most Recent
-
Int J Biol Macromol
Androgen receptor regulates the differentiation of myoblasts under cyclic mechanical stretch and its upstream and downstream signals. [Abstract]2024 Oct 2;281(Pt 1):136257. PMID: 39366623 -
Drug Test Anal
An in vitro assay approach to investigate the potential impact of different doping agents on the steroid profile. [Abstract]2021 May;13(5):916-928. PMID: 33283964 -
Drug Test Anal
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction. [Abstract]2021 Feb;13(2):283-298. PMID: 32852861 -
Solvente y solubilidad
In Vitro:
DMSO : ≥ 100 mg/mL (226.57 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
-
Ficha de datos (273 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Donghua Yin, et al. Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther. 2003 Mar;304(3):1334-40. [Content Brief]
[2]. Ioannis Simitsidellis, et al. Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus. J Endocrinol. 2019 Sep;242(3):227-239. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2657 mL | 11.3286 mL | 22.6572 mL | 56.6431 mL |
| 5 mM | 0.4531 mL | 2.2657 mL | 4.5314 mL | 11.3286 mL | |
| 10 mM | 0.2266 mL | 1.1329 mL | 2.2657 mL | 5.6643 mL | |
| 15 mM | 0.1510 mL | 0.7552 mL | 1.5105 mL | 3.7762 mL | |
| 20 mM | 0.1133 mL | 0.5664 mL | 1.1329 mL | 2.8322 mL | |
| 25 mM | 0.0906 mL | 0.4531 mL | 0.9063 mL | 2.2657 mL | |
| 30 mM | 0.0755 mL | 0.3776 mL | 0.7552 mL | 1.8881 mL | |
| 40 mM | 0.0566 mL | 0.2832 mL | 0.5664 mL | 1.4161 mL | |
| 50 mM | 0.0453 mL | 0.2266 mL | 0.4531 mL | 1.1329 mL | |
| 60 mM | 0.0378 mL | 0.1888 mL | 0.3776 mL | 0.9441 mL | |
| 80 mM | 0.0283 mL | 0.1416 mL | 0.2832 mL | 0.7080 mL | |
| 100 mM | 0.0227 mL | 0.1133 mL | 0.2266 mL | 0.5664 mL |
GTx-007 Related Classifications
HY-12023 Related Classifications
Powered by Bioz