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Referencia número: HY-112444

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BACE1-IN-2

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC₅₀ of 22 nM.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1352416-78-4
Fòrmula: C₁₉H₁₅F₄N₅O₂
Peso molecular:421.35

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BACE1-IN-2 Chemical Structure

No. CAS: 1352416-78-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC₅₀ of 22 nM^[1].

IC₅₀ & Target

BACE1

Ver todos los productos específicos de isoformas Beta-secretase :

BACE1
BACE2

In Vitro

BACE1-IN-2 (Compound 3) is 10-fold more potent toward BACE1 than BACE2, inhibition of which may lead to hair depigmentation. BACE1-IN-2 inhibits hAβ42 cell with an IC₅₀ of 6.0 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1352416-78-4
Peso molecular 421.35
Fòrmula C₁₉H₁₅F₄N₅O₂
SMILES

NC1=N[C@@](C2=C(F)C=CC(NC(C3=CC=C(C#N)C=N3)=O)=C2)(C)[C@H](C(F)(F)F)OC1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Gijsen HJM, et al. Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. J Med Chem. 2018 Jun 28;61(12):5292-5303. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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BACE1-IN-2

Verubecestat

LY2886721

Lanabecestat

LY2811376

AZD3839 free base

Elenbecestat

BACE1-IN-1

Verubecestat (Standard)

LY2811376 (Standard)

Elenbecestat (Standard)

BACE1-IN-1 (Standard)

Lanabecestat (Standard)

Ver todos los productos específicos de isoformas Beta-secretase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Bioz

BACE1-IN-2

Verubecestat

LY2886721

Lanabecestat

LY2811376

AZD3839 free base

Elenbecestat

BACE1-IN-1

Verubecestat (Standard)

LY2811376 (Standard)

Elenbecestat (Standard)

BACE1-IN-1 (Standard)

Lanabecestat (Standard)

Ver todos los productos específicos de isoformas Beta-secretase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

BACE1-IN-2 Related Classifications

HY-112444 Related Classifications

Bioz