CDN1163
Based on 18 publication(s) in Google Scholar
CDN1163 is an allosteric sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator that improves Ca2+ homeostasis. CDN1163 attenuates diabetes and metabolic disorders.
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- Pureza: 99.84%
- No. CAS: 892711-75-0
- Fòrmula: C20H20N2O2
- Peso molecular:320.39
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) CDN1163
More- Cell. 2025 Aug 1:S0092-8674(25)00801-3. [Abstract]
- Nat Commun. 2023 Feb 23;14(1):1020. [Abstract]
- Adv Sci (Weinh). 2025 Jul 25:e15313. [Abstract]
- Adv Sci (Weinh). 2025 Jun 26:e07210. [Abstract]
- Cancer Lett. 2023 Nov 28:577:216435. [Abstract]
- Phytomedicine. 2024 Aug 22:134:155958. [Abstract]
- J Hazard Mater. 2021 Sep 5:417:126025. [Abstract]
- Cell Death Discov. 2024 Jun 11;10(1):280. [Abstract]
- Free Radic Biol Med. 2024 Feb 20:212:284-294. [Abstract]
- Biochem Pharmacol. 2022 Sep:203:115164. [Abstract]
- Sci Rep. 2025 Dec 12. [Abstract]
- J Virol. 2021 Apr 26;95(10):e00217-21. [Abstract]
- Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]
- Hum Mol Genet. 2025 May 14:ddaf074. [Abstract]
- Behav Brain Res. 2021 Feb 5;399:112984. [Abstract]
- Addict Biol. 2024 Mar;29(3):e13382. [Abstract]
- Biochem Biophys Res Commun. 2023 Jul 12:665:124-132. [Abstract]
- bioRxiv. 2026 Mar 6.
Customer Validation & Images
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Cell Imaging/Staining
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Flow Cytometry
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WB
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Histological Imaging/Staining
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In Vivo Efficacy Study
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Actividad biológica
SERCA[1]
CDN1163 (10 μM; 24 hours; rat cardiac myocyte cells) treatment reduces high glucose-induced resistin and nuclear NFATc expression and increases the phosphorylation of AMPKα in a time-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rat cardiac myocyte cells (H9c2)
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Concentration:10 μM
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Incubation Time:24 hours
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Result:High glucose-induced resistin and nuclear NFATc expression are significantly reduced. The phosphorylation of AMPKα is increased in a time-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male 8-10-week old ob/ob mice and lean ob/+ mice[1]
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Dosage:50 mg/kg
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Administration:Intraperitoneal injection; for 5 days
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Result:Markedly lowered fasting blood glucose, improved glucose tolerance, and ameliorated hepatosteatosis but did not alter glucose levels or body weight. Increased expression of uncoupling protein 1 (UCP1) and UCP3 in brown adipose tissue and reduced the hepatic expression of genes involved in gluconeogenesis and lipogenesis, attenuated ER stress response and ER stress-induced apoptosis, and improved mitochondrial biogenesis, possibly through SERCA2-mediated activation of AMP-activated protein kinase pathway.
Chemical Information
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No. CAS 892711-75-0
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Appearance Solid
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Peso molecular 320.39
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Fòrmula C20H20N2O2
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Color White to off-white
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SMILES
O=C(NC1=C2N=C(C)C=CC2=CC=C1)C3=CC=C(OC(C)C)C=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (18)
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Journal Impact Factor
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Most Recent
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Cell
2025 Aug 1:S0092-8674(25)00801-3. PMID: 40763735 -
Nat Commun
THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass. [Abstract]2023 Feb 23;14(1):1020. PMID: 36823211 -
Adv Sci (Weinh)
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca2+ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium. [Abstract]2025 Jul 25:e15313. PMID: 40709664
CDN1163 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 25:e15313. [Abstract]
The THP1 cells were treated with 15 µM of LW‐213 with/without CDN‐1163 (50 µM) for 9 h. Cells were collected and crawled for immunofluorescence staining of cell nuclei for DAPI.
CDN1163 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 25:e15313. [Abstract]
Flow cytometric analysis of Annexin V‐FITC/PI‐PerCP‐stained cell line of Vector or TPCN1‐OE HeLa treated with 15 µM of LW‐213 with/without CDN‐1163 (50 µM) for 24 h.
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Adv Sci (Weinh)
Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models. [Abstract]2025 Jun 26:e07210. PMID: 40568929 -
Cancer Lett
2023 Nov 28:577:216435. PMID: 37806516 -
Phytomedicine
LW-213, a derivative of wogonin, triggers reticulophagy-mediated cell death in NSCLC via lysosomal damage combined with NPC1 inhibition. [Abstract]2024 Aug 22:134:155958. PMID: 39241385 -
J Hazard Mater
Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload. [Abstract]2021 Sep 5:417:126025. PMID: 34229379 -
Cell Death Discov
Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway. [Abstract]2024 Jun 11;10(1):280. PMID: 38862478
CDN1163 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Jun 11;10(1):280. [Abstract]
CDN1163 (1 μM) significantly inhibited the expressions of p-PERK and p-eIF2α proteins.
CDN1163 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Jun 11;10(1):280. [Abstract]
CDN1163 (20 mg/kg, i.p.) reversed the morphological changes in hippocampal tissue by HE staining.
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Free Radic Biol Med
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress. [Abstract]2024 Feb 20:212:284-294. PMID: 38163553 -
Biochem Pharmacol
Substitution of SERCA2 Cys674 aggravates cardiac fibrosis by promoting the transformation of cardiac fibroblasts to cardiac myofibroblasts. [Abstract]2022 Sep:203:115164. PMID: 35809651 -
Sci Rep
Pharmacological activation of SERCA2 reverses ER calcium dysregulation and depression-like behaviors in hyperglycemic mice. [Abstract]2025 Dec 12. PMID: 41387522 -
J Virol
Sarco/Endoplasmic Reticulum Ca2+ Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells. [Abstract]2021 Apr 26;95(10):e00217-21. PMID: 33692207 -
Food Chem Toxicol
Coexposure to fluoride and sulfur dioxide aggravates enamel mineralization disorders in mice by disrupting calcium homeostasis-mediated endoplasmic reticulum stress. [Abstract]2025 Feb 10:115317. PMID: 39938609 -
Hum Mol Genet
Neuromuscular junction transcriptome analysis of spinal and bulbar muscular atrophy mice implicates sarcomere gene expression and calcium flux dysregulation in disease pathogenesis. [Abstract]2025 May 14:ddaf074. PMID: 40366765 -
Behav Brain Res
Chronic but not acute pharmacological activation of SERCA induces behavioral and neurochemical effects in male and female mice. [Abstract]2021 Feb 5;399:112984. PMID: 33137400
CDN1163 purchased from MedChemExpress. Usage Cited in: Behav Brain Res. 2021 Feb 5;399:112984. [Abstract]
Chronic CDN1163 treatment induced an anxiogenic effect as the 10 mg/kg dose significantly decreased the time mice spent in the center of the OF arena.
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Addict Biol
Involvement of nucleus accumbens SERCA2b in methamphetamine-induced conditioned place preference. [Abstract]2024 Mar;29(3):e13382. PMID: 38488467 -
Biochem Biophys Res Commun
2023 Jul 12:665:124-132. PMID: 37156050 -
Solvente y solubilidad
DMSO : 100 mg/mL (312.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (7.80 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Kang S, et al. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J Biol Chem. 2016 Mar 4;291(10):5185-98. [Content Brief]
[2]. Singh R, et al. A role for calcium in resistin transcriptional activation in diabetic hearts. Sci Rep. 2018 Oct 23;8(1):15633. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1212 mL | 15.6060 mL | 31.2120 mL | 78.0299 mL |
| 5 mM | 0.6242 mL | 3.1212 mL | 6.2424 mL | 15.6060 mL | |
| 10 mM | 0.3121 mL | 1.5606 mL | 3.1212 mL | 7.8030 mL | |
| 15 mM | 0.2081 mL | 1.0404 mL | 2.0808 mL | 5.2020 mL | |
| 20 mM | 0.1561 mL | 0.7803 mL | 1.5606 mL | 3.9015 mL | |
| 25 mM | 0.1248 mL | 0.6242 mL | 1.2485 mL | 3.1212 mL | |
| 30 mM | 0.1040 mL | 0.5202 mL | 1.0404 mL | 2.6010 mL | |
| 40 mM | 0.0780 mL | 0.3901 mL | 0.7803 mL | 1.9507 mL | |
| 50 mM | 0.0624 mL | 0.3121 mL | 0.6242 mL | 1.5606 mL | |
| 60 mM | 0.0520 mL | 0.2601 mL | 0.5202 mL | 1.3005 mL | |
| 80 mM | 0.0390 mL | 0.1951 mL | 0.3901 mL | 0.9754 mL | |
| 100 mM | 0.0312 mL | 0.1561 mL | 0.3121 mL | 0.7803 mL |
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