D-Cycloserine
Based on 8 publication(s) in Google Scholar
D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes, with blood-brain barrier permeability. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.73%
- No. CAS: 68-41-7
- Fòrmula: C3H6N2O2
- Peso molecular:102.09
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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D-Cycloserine (Standard)
Publications Citing Use of MedChemExpress (MCE) D-Cycloserine
More- Nat Commun. 2026 Jul 7;17(1):8383.
- mLife. 2025 Apr 15;4(2):155-168. [Abstract]
- J Affect Disord. 2026 Feb 15;395(Pt A):120634. [Abstract]
- Molecules. 2025 Oct 23;30(21):4170. [Abstract]
- ACS Chem Biol. 2022 Jan 21;17(1):39-53. [Abstract]
- Biochem Biophys Res Commun. 2024 Aug 30:722:150074. [Abstract]
- Exp Brain Res. 2023 Dec;241(11-12):2735-2750. [Abstract]
- Research Square Preprint. 2021 Aug.
Customer Validation & Images
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Actividad biológica
Descripciòn
IC50 & Target
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NMDA Receptor |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
>1000 μM
Compound: Cycloserine
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Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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[PMID: 21965623] |
| Sf21 | IC50 |
>1000 μM
Compound: Cycloserine
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Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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[PMID: 21965623] |
| Vero | IC50 |
>62.5 μg/mL
Compound: Cycloserine
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Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
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[PMID: 23352268] |
| Vero | IC50 |
>100 μg/mL
Compound: Cycloserine
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Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay
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[PMID: 24087924] |
| Vero | IC50 |
>6.25 μg/mL
Compound: Cycloserine
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Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay
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[PMID: 28552337] |
In Vivo
Chronic D-Cycloserine (40 mg/kg; 5 days/week; for 2 weeks) significantly reduces nicotine self-administration selectively in rats with low baseline nicotine use, but is ineffective with the rats with higher levels of baseline nicotine self-administration[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 68-41-7
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Appearance Solid
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Peso molecular 102.09
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Fòrmula C3H6N2O2
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Color White to off-white
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SMILES
O=C1[C@H](N)CON1
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Structure Classification
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Initial Source
Streptomyces
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (8)
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Journal Impact Factor
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Most Recent
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mLife
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria. [Abstract]2025 Apr 15;4(2):155-168. PMID: 40313980 -
J Affect Disord
Enriched environment prevented glutamate receptor loss in the prefrontal cortex to alleviate CUMS-induced depression-like behaviors. [Abstract]2026 Feb 15;395(Pt A):120634. PMID: 41237964
D-Cycloserine purchased from MedChemExpress. Usage Cited in: J Affect Disord. 2026 Feb 15;395(Pt A):120634. [Abstract]
D-Cycloserine (DCS; 5 nM for 5 μL; i.c.v.) did not increase the time spent in the open field's central region in mice.
D-Cycloserine purchased from MedChemExpress. Usage Cited in: J Affect Disord. 2026 Feb 15;395(Pt A):120634. [Abstract]
D-Cycloserine (DCS; 5 nM for 5 μL; i.c.v.) did not increase the time spent in the open arms of the EPM or the number of entries into the open arms in mice.
D-Cycloserine purchased from MedChemExpress. Usage Cited in: J Affect Disord. 2026 Feb 15;395(Pt A):120634. [Abstract]
D-Cycloserine (DCS; 5 nM for 5 μL; i.c.v.) increased grooming time, while inducing a reduction in immobility duration within the TST in CUMS mice.
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Molecules
Identification of Marrubiin as a Cathepsin C Inhibitor for Treating Rheumatoid Arthritis. [Abstract]2025 Oct 23;30(21):4170. PMID: 41226133 -
ACS Chem Biol
Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. [Abstract]2022 Jan 21;17(1):39-53. PMID: 34908399 -
Biochem Biophys Res Commun
AMPA receptor potentiation alleviates NLRP3 knockout-induced fear generalization in mice. [Abstract]2024 Aug 30:722:150074. PMID: 38805785
D-Cycloserine purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Aug 30:722:150074. [Abstract]
D-Cycloserine (21.66 mg/kg; p.o.; daily for 5 days) failed to ameliorate fear generalization in NLRP3 KO mice.
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Exp Brain Res
The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults. [Abstract]2023 Dec;241(11-12):2735-2750. PMID: 37845379
D-Cycloserine purchased from MedChemExpress. Usage Cited in: Exp Brain Res. 2023 Dec;241(11-12):2735-2750. [Abstract]
D-Cycloserine (10 mg/kg; intraperitoneally 3 h after the MCAO surgery, given again after 24 h of reperfusion) did not reduce the infarct area of the mouse brain in the cerebral injuries of MCAO mice.
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Solvente y solubilidad
In Vitro:
H2O : 12.5 mg/mL (122.44 mM; ultrasonic and warming and heat to 60°C)
DMSO : 1 mg/mL (9.80 mM; Need warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 11.11 mg/mL (108.83 mM); Clear solution; Need ultrasonic
Protocolo
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Nitsche, M.A., et al., Consolidation of human motor cortical neuroplasticity by D-cycloserine. Neuropsychopharmacology, 2004. 29(8): p. 1573-8. [Content Brief]
[2]. Sarah Batson, et al. Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nat Commun. 2017 Dec 5;8(1):1939. [Content Brief]
[3]. Levin, E.D., et al., D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response. Pharmacol Biochem Behav, 2011. 98(2): p. 210-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 9.7953 mL | 48.9764 mL | 97.9528 mL | 244.8820 mL |
| 5 mM | 1.9591 mL | 9.7953 mL | 19.5906 mL | 48.9764 mL | |
| H2O | 10 mM | 0.9795 mL | 4.8976 mL | 9.7953 mL | 24.4882 mL |
| 15 mM | 0.6530 mL | 3.2651 mL | 6.5302 mL | 16.3255 mL | |
| 20 mM | 0.4898 mL | 2.4488 mL | 4.8976 mL | 12.2441 mL | |
| 25 mM | 0.3918 mL | 1.9591 mL | 3.9181 mL | 9.7953 mL | |
| 30 mM | 0.3265 mL | 1.6325 mL | 3.2651 mL | 8.1627 mL | |
| 40 mM | 0.2449 mL | 1.2244 mL | 2.4488 mL | 6.1220 mL | |
| 50 mM | 0.1959 mL | 0.9795 mL | 1.9591 mL | 4.8976 mL | |
| 60 mM | 0.1633 mL | 0.8163 mL | 1.6325 mL | 4.0814 mL | |
| 80 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0610 mL | |
| 100 mM | 0.0980 mL | 0.4898 mL | 0.9795 mL | 2.4488 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Cycloserine Related Classifications
HY-B0030 Related Classifications
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