Copy Link Print Information

GSK484 hydrochloride

54 Cited Publications
Revisión del cliente

Based on 54 publication(s) in Google Scholar

GSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed.

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza: 99.48%
  • No. CAS: 1652591-81-5
  • Fòrmula: C27H32ClN5O3
  • Peso molecular:510.03
  • Almacenamiento:

    4°C, stored under nitrogen, away from moisture

    * In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen, away from moisture)

  • GSK484 hydrochloride Chemical Structure
    GSK484 hydrochloride Chemical Structure
  • Experimental Validation Results for GSK484 hydrochloride
  • Experimental Validation Results for GSK484 hydrochloride
  • Experimental Validation Results for GSK484 hydrochloride
  • Experimental Validation Results for GSK484 hydrochloride
  • Experimental Validation Results for GSK484 hydrochloride
No. CAS: 1652591-81-5
Tamaño
Precio
Stock
Cantidad
Amount: USD 0.00
Please select quantity
or
or

* Seleccione Cantidad antes de agregar artículos.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of GSK484 hydrochloride:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
  • Actividad biológica
  • Chemical Information
  • Solvente y solubilidad
  • Protocolo
  • Pureza y Documentación
  • Referencias
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) GSK484 hydrochloride

More
Customer Validation & Images
In Vivo Efficacy Study
  • In Vivo Efficacy Study
  • In Vivo Efficacy Study
  • In Vivo Efficacy Study
  • In Vivo Efficacy Study
  • In Vivo Efficacy Study
Keywords
MOQ
Minimum order quantity
100 mg

Obtener un presupuesto En stock

Other size
Obtener un presupuesto
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Inicie sesiòn
Registrar
Sign in to MedChemExpress
Registrar una cuenta nueva

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • GSK484 hydrochloride Chemical Structure
    GSK484 hydrochloride Chemical Structure
    1/16
  • 1/16

    GSK484 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2025 Sep 8;43(9):1758-1775.e8. [Abstract]

    Customer Validation
     Schema for GSK484 treatment protocol and summary tumor growth curves of MC38 in Dnase1l3fl/fl and Dnase1l3cko mice (n = 7).

  • 1/16

    GSK484 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 Mar 8;39(3):423-437.e7. [Abstract]

    Customer Validation
     Mice were treated with GSK484 (20 mg/kg, i.p. daily shots for 20 days from day 7, and then maintenance shots every two days) following orthotopic injection of AT3 cells. Shown are BLI quantification of primary tumor growth at day 19.

  • 1/16

    GSK484 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 Mar 8;39(3):423-437.e7. [Abstract]

    Customer Validation
     Mice were treated with GSK484 (20 mg/kg, i.p. daily shots for 20 days from day 7, and then maintenance shots every two days) following orthotopic injection of AT3 cells. Shown are BLI quantification of lung metastasis at week 5.

  • 1/16

    GSK484 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 Mar 8;39(3):423-437.e7. [Abstract]

    Customer Validation
     Mice were treated with GSK484 (20 mg/kg, i.p. daily shots for 20 days from day 7, and then maintenance shots every two days) following orthotopic injection of AT3 cells. Shown are pulmonary surface nodules at week 5.

  • 1/16

    GSK484 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 Mar 8;39(3):423-437.e7. [Abstract]

    Customer Validation
     Mice were treated with GSK484 (20 mg/kg, i.p. daily shots for 20 days from day 7, and then maintenance shots every two days) following orthotopic injection of AT3 cells. Shown are NET formation in lung metastases.

  • GSK484 hydrochloride