PPQ-102
Based on 4 publication(s) in Google Scholar
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.73%
- No. CAS: 931706-15-9
- Fòrmula: C26H22N4O3
- Peso molecular:438.48
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PPQ-102
More
Actividad biológica
Descripciòn
IC50 & Target
IC50: ~90 nM (CFTR)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Epithelial cell | IC50 |
<1 μM
Compound: PPQ-102
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Inhibition of CFTR in nonpermeabilized human bronchial epithelial cells assessed as inhibition of forskolin and IBMX-induced chloride current at by short-circuit current analysis
Inhibition of CFTR in nonpermeabilized human bronchial epithelial cells assessed as inhibition of forskolin and IBMX-induced chloride current at by short-circuit current analysis
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[PMID: 19785436] |
| T84 | IC50 |
<1 μM
Compound: PPQ-102
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Inhibition of CFTR in nonpermeabilized human T84 cells assessed as inhibition of forskolin and IBMX-induced chloride current by short-circuit current analysis
Inhibition of CFTR in nonpermeabilized human T84 cells assessed as inhibition of forskolin and IBMX-induced chloride current by short-circuit current analysis
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[PMID: 19785436] |
In Vitro
PPQ-102 (0, 0.5, 5μM, 4 days) prevents and reverses renal cyst expansion in an embryonic kidney organ culture model of PKD[1].
PPQ-102 (0, 0.5, 5μM, 3 days) shows ability of reducing fluid accumulation in preformed cysts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:E13.5 embryonic kidneys (embryonic kidney organ culture model of PKD)
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Concentration:0, 0.5, 5 μM
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Incubation Time:3 or 4 days
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Result:Remarkablyreduced the number and size of renal cysts formed in the 8-Br-cAMP-containing medium (showed ∼60% inhibition of cyst formation at 0.5 μM, near complete absence of cysts at 2.5 and 5 μM).
Remarkable reduced cyst size over 1 and 2 days in the 8-Br-cAMP-containing medium.
Chemical Information
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No. CAS 931706-15-9
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Appearance Solid
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Peso molecular 438.48
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Fòrmula C26H22N4O3
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Color Light yellow to yellow
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SMILES
CN1C(C2=C(C3=CC=CC=C3)N4C5=CC=CC=C5NC(C6=CC=C(C)O6)C4=C2N(C)C1=O)=O
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Synonyms
CFTR Inhibitor
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
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Drug Resist Updat
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer. [Abstract]2023 Nov:71:101005. PMID: 37647746 -
Virulence
LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells. [Abstract]2023 Dec;14(1):2287339. PMID: 38018865 -
J Physiol
2025 May;603(9):2619-2632. PMID: 40047394 -
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (114.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (5.70 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2806 mL | 11.4030 mL | 22.8061 mL | 57.0151 mL |
| 5 mM | 0.4561 mL | 2.2806 mL | 4.5612 mL | 11.4030 mL | |
| 10 mM | 0.2281 mL | 1.1403 mL | 2.2806 mL | 5.7015 mL | |
| 15 mM | 0.1520 mL | 0.7602 mL | 1.5204 mL | 3.8010 mL | |
| 20 mM | 0.1140 mL | 0.5702 mL | 1.1403 mL | 2.8508 mL | |
| 25 mM | 0.0912 mL | 0.4561 mL | 0.9122 mL | 2.2806 mL | |
| 30 mM | 0.0760 mL | 0.3801 mL | 0.7602 mL | 1.9005 mL | |
| 40 mM | 0.0570 mL | 0.2851 mL | 0.5702 mL | 1.4254 mL | |
| 50 mM | 0.0456 mL | 0.2281 mL | 0.4561 mL | 1.1403 mL | |
| 60 mM | 0.0380 mL | 0.1901 mL | 0.3801 mL | 0.9503 mL | |
| 80 mM | 0.0285 mL | 0.1425 mL | 0.2851 mL | 0.7127 mL | |
| 100 mM | 0.0228 mL | 0.1140 mL | 0.2281 mL | 0.5702 mL |
PPQ-102 Related Classifications
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