Propionylcarnitine
Based on 1 Customer Validation
Propionylcarnitine is metabolized by carnitine acetyltransferase from propionyl-CoA. Increased propionylcarnitine is regarded as a biomarker of vitamin B12 deficiency.
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- Pureza: 99.80%
- No. CAS: 17298-37-2
- Fòrmula: C10H19NO4
- Peso molecular:217.26
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Human Endogenous Metabolite |
Propionylcarnitine shows protection to beta-thalassaemic erythrocytes from oxidative stress[3]. Propionylcarnitine increases production of 14CO2 from [1-14C]pyruvate and increases the rate of formation of acetyl camitine from pyruvate[4]. Propionylcarnitine allows the endothelial cells to maintain their functionality and regulatory role on vessel activity for a longer time and decreases the formation of oxygen reactive species due to xanthine oxidase activity on hypoxanthine formed by adenine nucleotide catabolism[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult age-matched male C57BL/6 mice[5]
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Dosage:2 mM/kg/day
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Administration:Oral gavage; 2 mM/kg/day for 4 weeks
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Result:Increased plasma and urine total carnitine concentrations, but showed no effect on the skeletal muscle carnitine content of mice.
Chemical Information
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No. CAS 17298-37-2
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Appearance Solid
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Peso molecular 217.26
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Fòrmula C10H19NO4
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Color White to off-white
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SMILES
CCC(OC(CC([O-])=O)C[N+](C)(C)C)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 125 mg/mL (575.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (460.28 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (9.57 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (9.57 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Jacobs PL, et al. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr. 2009;6:9. Published 2009 Apr 2. [Content Brief]
[2]. Kowal A, et al. Propionylcarnitine and methionine concentrations in newborns with hypospadias. Cent European J Urol. 2013;66(3):377-380. [Content Brief]
[3]. Palmieri L, et al. Protection of beta-thalassaemic erythrocytes from oxidative stress by propionyl carnitine. Int J Tissue React. 1994;16(3):121-9. [Content Brief]
[4]. Tassani V, et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. Biochem Biophys Res Commun. 1994 Mar 15;199(2):949-53. [Content Brief]
[5]. Morand R, et al. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. Eur J Nutr. 2014 Sep;53(6):1313-25. [Content Brief]
[6]. Bertelli A, et al. Effect of propionyl carnitine on energy charge and adenine nucleotide content of cardiac endothelial cells during hypoxia. Int J Tissue React. 1991;13(1):37-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 4.6028 mL | 23.0139 mL | 46.0278 mL | 115.0695 mL |
| 5 mM | 0.9206 mL | 4.6028 mL | 9.2056 mL | 23.0139 mL | |
| 10 mM | 0.4603 mL | 2.3014 mL | 4.6028 mL | 11.5070 mL | |
| 15 mM | 0.3069 mL | 1.5343 mL | 3.0685 mL | 7.6713 mL | |
| 20 mM | 0.2301 mL | 1.1507 mL | 2.3014 mL | 5.7535 mL | |
| 25 mM | 0.1841 mL | 0.9206 mL | 1.8411 mL | 4.6028 mL | |
| 30 mM | 0.1534 mL | 0.7671 mL | 1.5343 mL | 3.8357 mL | |
| 40 mM | 0.1151 mL | 0.5753 mL | 1.1507 mL | 2.8767 mL | |
| 50 mM | 0.0921 mL | 0.4603 mL | 0.9206 mL | 2.3014 mL | |
| 60 mM | 0.0767 mL | 0.3836 mL | 0.7671 mL | 1.9178 mL | |
| 80 mM | 0.0575 mL | 0.2877 mL | 0.5753 mL | 1.4384 mL | |
| 100 mM | 0.0460 mL | 0.2301 mL | 0.4603 mL | 1.1507 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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