R162
Based on 16 publication(s) in Google Scholar
R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.89%
- No. CAS: 64302-87-0
- Fòrmula: C17H12O3
- Peso molecular:264.28
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Glutamine Metabolism Compound Library
HY-L064
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Anti-Cancer Metabolism Compound Library
HY-L083
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Targeted Diversity Library
HY-L099
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Amino Acid Metabolism Compound Library
HY-L189
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) R162
More- Cell. 2026 Jan 22;189(2):418-434.e24. [Abstract]
- Cancer Discov. 2026 Apr 7. [Abstract]
- Sci Bull. 2026 May 15;71(9):2283-2299. [Abstract]
- Cancer Res. 2022 Sep 16;82(18):3223-3235. [Abstract]
- Acta Pharm Sin B. 2022 Feb;12(2):759-773. [Abstract]
- Adv Sci (Weinh). 2025 Jan;12(1):e2310308. [Abstract]
- Sci Adv. 2025 Aug 29;11(35):eadu6271. [Abstract]
- Cell Death Dis. 2023 Jul 29;14(7):481. [Abstract]
- Cell Death Dis. 2022 May 20;13(5):479. [Abstract]
- Cell Death Discov. 2025 Oct 6;11(1):430. [Abstract]
- Antioxidants (Basel). 2021 Aug 25;10(9):1349. [Abstract]
- Biochem Pharmacol. 2025 Dec;242(Pt 4):117443. [Abstract]
- Commun Biol. 2023 Jul 7;6(1):696. [Abstract]
- PLoS Pathog. 2024 Jun 21;20(6):e1012305. [Abstract]
- FEBS J. 2024 Oct;291(20):4581-4601. [Abstract]
- bioRxiv. 2021 Mar 8.
Customer Validation & Images
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Apoptosis Analysis
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Cell Imaging/Staining
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WB
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Bio/Physico-chemical Assay
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In Vivo Efficacy Study
Actividad biológica
Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 64302-87-0
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Appearance Solid
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Peso molecular 264.28
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Fòrmula C17H12O3
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Color Light yellow to yellow
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SMILES
O=C1C2=C(C=CC=C2)C(C3=CC=C(CC=C)C(O)=C13)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (16)
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Journal Impact Factor
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Most Recent
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Cell
Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity. [Abstract]2026 Jan 22;189(2):418-434.e24. PMID: 41448182 -
Cancer Discov
Correcting Mitochondrial Complex I Defect in Tumor-Associated Natural Killer Cells Potentiates Immunotherapy for Glioblastoma. [Abstract]2026 Apr 7. PMID: 41944586 -
Sci Bull
Hepatic IFRD1 suppresses metabolic dysfunction-associated fatty liver disease via GLUD1/α-KG axis. [Abstract]2026 May 15;71(9):2283-2299. PMID: 41997855 -
Cancer Res
GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors. [Abstract]2022 Sep 16;82(18):3223-3235. PMID: 35895805 -
Acta Pharm Sin B
Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability. [Abstract]2022 Feb;12(2):759-773. PMID: 35256945
R162 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Feb;12(2):759-773. [Abstract]
R162 (20 μM, 48 h) inhibited GDH1 and resulted in greatly increased cell apoptosis.
R162 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Feb;12(2):759-773. [Abstract]
CAI, CB-839, or R162 (20 μM, 48 h) alone slightly increased the generation of intracellular ROS, whereas ROS generation was significantly increased in the combination group.
R162 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Feb;12(2):759-773. [Abstract]
Western blots showing the expressions of caspase 3, cleaved caspase 3, caspase 6, cleaved caspase 6, caspase 7 and cleaved caspase 7 after 48 h of CAI (10 μmol/L), CB-839 (100 nmol/L), CAI + CB-839, R162 (20 μmol/L) or CAI + R162.
R162 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Feb;12(2):759-773. [Abstract]
The ratio of GSH to GSSG in HCT116 cells and C26 cells with CAI (10 μmol/L), CB-839 (100 nmol/L), CAI + CB-839, R162 (20 μmol/L) or CAI + R162 for 48 h.
R162 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Feb;12(2):759-773. [Abstract]
Nude mice bearing 5 mm × 5 mm C26 cell tumors were treated with PBS, CAI (20 mg/kg), CB-839 (200 mg/kg), or CAI/CB-839 or PBS, CAI, R162 (20 mg/kg), or CAI/R162 for 21 days. The tumor growth curves of tumor-bearing mice receiving various treatments.
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Adv Sci (Weinh)
Inhibition of Glutamate-to-Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells. [Abstract]2025 Jan;12(1):e2310308. PMID: 39482885 -
Sci Adv
Glutamate utilization fuels rapid production of mitochondrial ROS in dendritic cells and drives systemic inflammation during tularemia. [Abstract]2025 Aug 29;11(35):eadu6271. PMID: 40880474 -
Cell Death Dis
Epigenetic activation of secretory phenotypes in senescence by the FOXQ1-SIRT4-GDH signaling. [Abstract]2023 Jul 29;14(7):481. PMID: 37516739 -
Cell Death Dis
Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer. [Abstract]2022 May 20;13(5):479. PMID: 35595754 -
Cell Death Discov
Metabolic interplay between exogenous cystine and glutamine dependence in triple-negative breast cancer. [Abstract]2025 Oct 6;11(1):430. PMID: 41053011 -
Antioxidants (Basel)
Glutamine Modulates Expression and Function of Glucose 6-Phosphate Dehydrogenase via NRF2 in Colon Cancer Cells. [Abstract]2021 Aug 25;10(9):1349. PMID: 34572981 -
Biochem Pharmacol
Targeting glutamine catabolism suppresses eosinophil expansion and activation to alleviate allergic airway inflammation. [Abstract]2025 Dec;242(Pt 4):117443. PMID: 41125213 -
Commun Biol
Elevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy. [Abstract]2023 Jul 7;6(1):696. PMID: 37419968 -
PLoS Pathog
PoRVA G9P[23] and G5P[7] infections differentially promote PEDV replication by reprogramming glutamine metabolism. [Abstract]2024 Jun 21;20(6):e1012305. PMID: 38905309 -
FEBS J
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator-activated receptor gamma. [Abstract]2024 Oct;291(20):4581-4601. PMID: 39136063 -
Solvente y solubilidad
DMSO : 10 mg/mL (37.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 1 mg/mL (3.78 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 3.7839 mL | 18.9193 mL | 37.8387 mL | 94.5966 mL |
| DMSO | 5 mM | 0.7568 mL | 3.7839 mL | 7.5677 mL | 18.9193 mL |
| 10 mM | 0.3784 mL | 1.8919 mL | 3.7839 mL | 9.4597 mL | |
| 15 mM | 0.2523 mL | 1.2613 mL | 2.5226 mL | 6.3064 mL | |
| 20 mM | 0.1892 mL | 0.9460 mL | 1.8919 mL | 4.7298 mL | |
| 25 mM | 0.1514 mL | 0.7568 mL | 1.5135 mL | 3.7839 mL | |
| 30 mM | 0.1261 mL | 0.6306 mL | 1.2613 mL | 3.1532 mL |
R162 Related Classifications
HY-103096 Related Classifications
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